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    hgo homogentisate 1,2-dioxygenase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34552, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hgoprovided by FlyBase
    Official Full Name
    homogentisate 1,2-dioxygenaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0040211
    Locus tag
    Dmel_CG4779
    See related
    AllianceGenome:FB:FBgn0040211
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4779; Dmel\CG4779; Hgo; HGO
    Summary
    Predicted to enable homogentisate 1,2-dioxygenase activity. Predicted to be involved in L-phenylalanine catabolic process. Is expressed in adult head; dorsal imaginal tissue; embryonic dorsal epidermis; and embryonic ventral epidermis. Used to study alkaptonuria. Human ortholog(s) of this gene implicated in alkaptonuria. Orthologous to human HGD (homogentisate 1,2-dioxygenase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See hgo in Genome Data Viewer
    Location:
    32D5-32D5; 2-44 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (11136393..11138565)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (11136393..11138565)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Nucleoporin 160kD Neighboring gene Replication factor C 38kD subunit Neighboring gene uncharacterized protein Neighboring gene Guanylyl cyclase at 32E Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tyrosine Metabolism Pathway Is Downregulated in Dopaminergic Neurons with LRRK2 Overexpression in Drosophila. Cheng J, et al. Int J Mol Sci, 2023 Oct 25. PMID 37958569, Free PMC Article
    2. Downregulation of the tyrosine degradation pathway extends Drosophila lifespan. Parkhitko AA, et al. Elife, 2020 Dec 15. PMID 33319750, Free PMC Article
    3. Stable Binding of the Conserved Transcription Factor Grainy Head to its Target Genes Throughout Drosophila melanogaster Development. Nevil M, et al. Genetics, 2017 Feb. PMID 28007888, Free PMC Article
    4. Proteomic Analysis of Red Ginseng on Prolonging the Life Span of Male Drosophila melanogaster. Hou W, et al. Front Pharmacol, 2021. PMID 34177563, Free PMC Article
    5. A Drosophila model of the neurodegenerative disease SCA17 reveals a role of RBP-J/Su(H) in modulating the pathological outcome. Ren J, et al. Hum Mol Genet, 2011 Sep 1. PMID 21653638, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables homogentisate 1,2-dioxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables homogentisate 1,2-dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-phenylalanine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in L-phenylalanine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tyrosine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    homogentisate 1,2-dioxygenase
    Names
    CG4779-PA
    hgo-PA
    NP_523544.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      11136393..11138565
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078820.3 → NP_523544.2  homogentisate 1,2-dioxygenase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523544.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q86P40, Q9VKJ0
      Related
      FBpp0079790
      Conserved Domains (1) summary
      TIGR01015
      Location:3 → 434
      hmgA; homogentisate 1,2-dioxygenase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VKJ0.3 Q9VKJ0

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