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    Ptr Patched-related [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35546, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ptrprovided by FlyBase
    Official Full Name
    Patched-relatedprovided by FlyBase
    Primary source
    FLYBASE:FBgn0262867
    Locus tag
    Dmel_CG11212
    See related
    AllianceGenome:FB:FBgn0262867
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11212; Dmel\CG11212; Dmptr; ptc-related-gene; ptr; Ptr_Dm
    Summary
    Predicted to be involved in cognition. Located in cytoplasmic vesicle membrane and plasma membrane. Is expressed in several structures, including adult head; anlage in statu nascendi; antennal anlage; epithelium; and head epidermis primordium. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to several human genes including PTCHD1 (patched domain containing 1) and PTCHD4 (patched domain containing 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ptr in Genome Data Viewer
    Location:
    42A13-42A13; 2-55 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (6181748..6196320, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (2069253..2083825, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene transfer RNA:Asparagine-GTT 1-7 Neighboring gene transfer RNA:Asparagine-GTT 1-8 Neighboring gene uncharacterized protein Neighboring gene eukaryotic translation initiation factor 3 subunit f2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular characterization of a novel patched-related protein in Apis mellifera and Drosophila melanogaster. Pastenes L, et al. Arch Insect Biochem Physiol, 2008 Jul. PMID 18563713
    2. Spatial and temporal distribution of Patched-related protein in the Drosophila embryo. Bolatto C, et al. Gene Expr Patterns, 2015 Sep-Nov. PMID 26506022
    3. Patched-Related Is Required for Proper Development of Embryonic Drosophila Nervous System. Bolatto C, et al. Front Neurosci, 2022. PMID 36081658, Free PMC Article
    4. The sterol-sensing domain: multiple families, a unique role? Kuwabara PE, et al. Trends Genet, 2002 Apr. PMID 11932020
    5. Discovery and functional prioritization of Parkinson's disease candidate genes from large-scale whole exome sequencing. Jansen IE, et al. Genome Biol, 2017 Jan 30. PMID 28137300, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cognition ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasmic vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Patched-related
    Names
    CG11212-PA
    CG11212-PB
    CG11212-PC
    CG11212-PD
    CG11212-PE
    Ptc related
    Ptc-related
    Ptc-related Disp-like
    Ptr-PA
    Ptr-PB
    Ptr-PC
    Ptr-PD
    Ptr-PE
    patched-related
    ptc-related gene

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      6181748..6196320 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259217.2 → NP_001246146.1  Patched-related, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246146.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86P36
      Conserved Domains (2) summary
      pfam02460
      Location:53 → 845
      Patched; Patched family
      pfam12349
      Location:295 → 442
      Sterol-sensing; Sterol-sensing domain of SREBP cleavage-activation

    2. NM_001259216.2 → NP_001246145.1  Patched-related, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246145.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86P36
      Conserved Domains (2) summary
      pfam02460
      Location:53 → 845
      Patched; Patched family
      pfam12349
      Location:295 → 442
      Sterol-sensing; Sterol-sensing domain of SREBP cleavage-activation

    3. NM_136365.3 → NP_610209.2  Patched-related, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610209.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86P36
      Related
      FBpp0085347
      Conserved Domains (2) summary
      pfam02460
      Location:53 → 845
      Patched; Patched family
      pfam12349
      Location:295 → 442
      Sterol-sensing; Sterol-sensing domain of SREBP cleavage-activation

    4. NM_001273793.1 → NP_001260722.1  Patched-related, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260722.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KED8
      Conserved Domains (1) summary
      TIGR00917
      Location:12 → 89
      2A060601; Niemann-Pick C type protein family

    5. NM_001273794.1 → NP_001260723.1  Patched-related, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260723.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KEC6
      Conserved Domains (1) summary
      TIGR00917
      Location:12 → 89
      2A060601; Niemann-Pick C type protein family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KEC6 A0A0B4KEC6
    A0A0B4KED8 A0A0B4KED8
    Q86P36 Q86P36

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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