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    wuc Wake-up-call [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36401, updated on 9-Dec-2024

    Summary

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    Official Symbol
    wucprovided by FlyBase
    Official Full Name
    Wake-up-callprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033770
    Locus tag
    Dmel_CG12442
    See related
    AllianceGenome:FB:FBgn0033770
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    147114_at; BcDNA:AT27450; CG12442; Dmel\CG12442
    Summary
    Involved in negative regulation of transcription by RNA polymerase II and spermatogenesis. Located in chromatin. Is active in nucleus. Is expressed in primary spermatocyte and testis. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See wuc in Genome Data Viewer
    Location:
    49C1-49C1; 2-67 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12700081..12700851)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8587586..8588356)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Odorant-binding protein 49a Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Mos oncogene Neighboring gene Tafazzin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A transposon expression burst accompanies the activation of Y-chromosome fertility genes during Drosophila spermatogenesis. Lawlor MA, et al. Nat Commun, 2021 Nov 25. PMID 34824217, Free PMC Article
    2. The polyubiquitin gene Ubi-p63E is essential for male meiotic cell cycle progression and germ cell differentiation in Drosophila. Lu C, et al. Development, 2013 Sep. PMID 23884444, Free PMC Article
    3. Tissue, cell type and stage-specific ectopic gene expression and RNAi induction in the Drosophila testis. White-Cooper H. Spermatogenesis, 2012 Jan 1. PMID 22553486, Free PMC Article
    4. Deficiency of ValRS-m Causes Male Infertility in Drosophila melanogaster. Duan X, et al. Int J Mol Sci, 2024 Jul 8. PMID 39000597, Free PMC Article
    5. Transcriptional regulation during Drosophila spermatogenesis. Lim C, et al. Spermatogenesis, 2012 Jul 1. PMID 23087835, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Wuc represses testis-specific gene expression, and this repression is counteracted by aly.
      Title: Wake-up-call, a lin-52 paralogue, and Always early, a lin-9 homologue physically interact, but have opposing functions in regulating testis-specific gene expression.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermatogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of DRM complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Wake-up-call
    Names
    CG12442-PA
    CG12442-PB
    wake-up-call
    wuc-PA
    wuc-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      12700081..12700851
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001103821.2 → NP_001097291.1  Wake-up-call, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097291.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z949, Q8MZ81
      Conserved Domains (1) summary
      pfam10044
      Location:57 → 127
      LIN52; Retinal tissue protein

    2. NM_136970.3 → NP_610814.1  Wake-up-call, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610814.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z949, Q8MZ81
      Related
      FBpp0086962
      Conserved Domains (1) summary
      pfam10044
      Location:57 → 127
      LIN52; Retinal tissue protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z949 A1Z949
    Q8MZ81 Q8MZ81

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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