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    Ppa Partner of paired [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37602, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ppaprovided by FlyBase
    Official Full Name
    Partner of pairedprovided by FlyBase
    Primary source
    FLYBASE:FBgn0020257
    Locus tag
    Dmel_CG9952
    See related
    AllianceGenome:FB:FBgn0020257
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9952; Dmel\CG9952; FBXL14; I-55; ppa; PPA
    Summary
    Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Is expressed in several structures, including anlage in statu nascendi; antennal anlage; antennal primordium; ganglia; and head epidermis primordium. Orthologous to human FBXL14 (F-box and leucine rich repeat protein 14). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ppa in Genome Data Viewer
    Location:
    59A1-59A2; 2-101 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (22684955..22688987, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (18572460..18576492, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44761 Neighboring gene Ring and YY1 Binding Protein Neighboring gene long non-coding RNA:CR44762 Neighboring gene long non-coding RNA:CR44763

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The F-box gene Ppa promotes lipid storage in Drosophila. Yang GW, et al. Yi Chuan, 2021 Jun 20. PMID 34284991
    2. Targeted localized degradation of Paired protein in Drosophila development. Raj L, et al. Curr Biol, 2000 Oct 19. PMID 11069107
    3. Pairing partners. Greaves S. Nat Cell Biol, 2000 Dec. PMID 11146666
    4. The F box protein partner of paired regulates stability of Drosophila centromeric histone H3, CenH3(CID). Moreno-Moreno O, et al. Curr Biol, 2011 Sep 13. PMID 21871803
    5. The E3-ligases SCFPpa and APC/CCdh1 co-operate to regulate CENP-ACID expression across the cell cycle. Moreno-Moreno O, et al. Nucleic Acids Res, 2019 Apr 23. PMID 30753559, Free PMC Article

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISM
    Inferred from Sequence Model
    more info
    		  
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SCF ubiquitin ligase complex ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    partner of paired
    Names
    CG9952-PA
    CG9952-PB
    CG9952-PC
    Ppa-PA
    Ppa-PB
    Ppa-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      22684955..22688987 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299814.1 → NP_001286743.1  partner of paired, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286743.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W214
      Conserved Domains (3) summary
      sd00034
      Location:263 → 288
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:149 → 190
      F-box-like; F-box-like
      cl28166
      Location:347 → 524
      AMN1; Antagonist of mitotic exit network protein 1

    2. NM_079088.3 → NP_523812.1  partner of paired, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523812.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W214
      Related
      FBpp0071835
      Conserved Domains (3) summary
      sd00034
      Location:263 → 288
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:149 → 190
      F-box-like; F-box-like
      cl28166
      Location:347 → 524
      AMN1; Antagonist of mitotic exit network protein 1

    3. NM_001274209.2 → NP_001261138.1  partner of paired, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261138.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KF28
      Conserved Domains (3) summary
      cd09293
      Location:347 → 524
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:263 → 288
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:149 → 190
      F-box-like; F-box-like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KF28 A0A0B4KF28
    Q9W214 Q9W214

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