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    CG12605 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38468, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG12605provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035481
    Locus tag
    Dmel_CG12605
    See related
    AllianceGenome:FB:FBgn0035481
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0140519.93; Dmel\CG12605
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nuclear body. Is expressed in central brain primordium; embryonic brain; larval ventral nerve cord; organism; and ventral nerve cord primordium. Orthologous to human SCRT1 (scratch family transcriptional repressor 1) and SCRT2 (scratch family transcriptional repressor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG12605 in Genome Data Viewer
    Location:
    64A1-64A1; 3-10 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (3954251..3964771, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (3954251..3964771, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene scratch

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Selective maintenance of Drosophila tandemly arranged duplicated genes during evolution. Quijano C, et al. Genome Biol, 2008. PMID 19087263, Free PMC Article
    2. Systematic identification and characterization of repressive domains in Drosophila transcription factors. Klaus L, et al. EMBO J, 2023 Feb 1. PMID 36545802, Free PMC Article
    3. Synergistic activation by Glass and Pointed promotes neuronal identity in the Drosophila eye disc. Wang H, et al. Nat Commun, 2024 Aug 17. PMID 39154080, Free PMC Article
    4. Pervasive variation of transcription factor orthologs contributes to regulatory network evolution. Nadimpalli S, et al. PLoS Genet, 2015 Mar. PMID 25748510, Free PMC Article
    5. Analysis of the eye developmental pathway in Drosophila using DNA microarrays. Michaut L, et al. Proc Natl Acad Sci U S A, 2003 Apr 1. PMID 12655063, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nuclear body ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG12605-PA
    CG12605-PB
    CG12605-PC
    CG12605-PD
    CG12605-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      3954251..3964771 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274458.1 → NP_001261387.1  uncharacterized protein Dmel_CG12605, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261387.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q29R14, Q8SZN0
      Conserved Domains (5) summary
      COG5048
      Location:492 → 570
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:498 → 518
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:441 → 461
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:524 → 546
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:511 → 534
      zf-H2C2_2; Zinc-finger double domain

    2. NM_206275.3 → NP_995997.1  uncharacterized protein Dmel_CG12605, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995997.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q29R14, Q8SZN0
      Conserved Domains (5) summary
      COG5048
      Location:492 → 570
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:498 → 518
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:441 → 461
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:524 → 546
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:511 → 534
      zf-H2C2_2; Zinc-finger double domain

    3. NM_206274.3 → NP_995996.1  uncharacterized protein Dmel_CG12605, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995996.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D2NUG4, Q7KV66
      Conserved Domains (5) summary
      COG5048
      Location:347 → 425
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:353 → 373
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:296 → 316
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:379 → 401
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:366 → 389
      zf-H2C2_2; Zinc-finger double domain

    4. NM_139588.4 → NP_647845.2  uncharacterized protein Dmel_CG12605, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647845.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q29R14, Q8SZN0
      Related
      FBpp0073023
      Conserved Domains (5) summary
      COG5048
      Location:492 → 570
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:498 → 518
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:441 → 461
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:524 → 546
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:511 → 534
      zf-H2C2_2; Zinc-finger double domain

    5. NM_001274459.1 → NP_001261388.1  uncharacterized protein Dmel_CG12605, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261388.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q29R14, Q8SZN0
      Conserved Domains (5) summary
      COG5048
      Location:492 → 570
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:498 → 518
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:441 → 461
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:524 → 546
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:511 → 534
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q29R14 Q29R14
    Q7KV66 Q7KV66
    Q8SZN0 Q8SZN0

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