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    Pura Puratrophin-1-like [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 2768948, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Puraprovided by FlyBase
    Official Full Name
    Puratrophin-1-likeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035802
    Locus tag
    Dmel_CG33275
    See related
    AllianceGenome:FB:FBgn0035802
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG33167; CG33275; CG7511; CG7513; CG7515; CG7520; Dmel\CG33275
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Involved in imaginal disc-derived leg morphogenesis; neuron projection morphogenesis; and regulation of locomotor rhythm. Is expressed in several structures, including adult heart; cuboidal/columnar epithelium; embryonic head epidermis; glial cell; and imaginal disc. Orthologous to several human genes including PLEKHG4B (pleckstrin homology and RhoGEF domain containing G4B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Pura in Genome Data Viewer
    Location:
    66A6-66A8; 3-21 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (7593091..7639573)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (7586191..7632673)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene missing minor mitochondria Neighboring gene testis-specific gamma-tubulin ring protein 84 Neighboring gene long non-coding RNA:CR45866 Neighboring gene ncRNA Neighboring gene Ubiquitin-related modifier 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Hox transcription factor Ultrabithorax binds RNA and regulates co-transcriptional splicing through an interplay with RNA polymerase II. Carnesecchi J, et al. Nucleic Acids Res, 2022 Jan 25. PMID 34931250, Free PMC Article
    2. A comparison of midline and tracheal gene regulation during Drosophila development. Long SK, et al. PLoS One, 2014. PMID 24465586, Free PMC Article
    3. Constraints, independence, and evolution of thermal plasticity: probing genetic architecture of long- and short-term thermal acclimation. Gerken AR, et al. Proc Natl Acad Sci U S A, 2015 Apr 7. PMID 25805817, Free PMC Article
    4. Distinct genomic signals of lifespan and life history evolution in response to postponed reproduction and larval diet in Drosophila. Hoedjes KM, et al. Evol Lett, 2019 Dec. PMID 31867121, Free PMC Article
    5. Drosophila hedgehog signaling and engrailed-runt mutual repression direct midline glia to alternative ensheathing and non-ensheathing fates. Watson JD, et al. Development, 2011 Apr. PMID 21350018, Free PMC Article

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in imaginal disc-derived leg morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron projection morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of Rho protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of locomotor rhythm IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    Puratrophin-1-like
    Names
    CG33275-PA
    CG33275-PB
    CG33275-PC
    CG33275-PD
    Pura-PA
    Pura-PB
    Pura-PC
    Pura-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      7593091..7639573
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_206294.3 → NP_996016.2  Puratrophin-1-like, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996016.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KU89
      Conserved Domains (4) summary
      cd13242
      Location:1524 → 1663
      PH_puratrophin-1; Puratrophin-1 pleckstrin homology (PH) domain
      pfam00169
      Location:1562 → 1655
      PH; PH domain
      pfam00621
      Location:1353 → 1532
      RhoGEF; RhoGEF domain
      cl02563
      Location:15 → 52
      PX_domain; The Phox Homology domain, a phosphoinositide binding module

    2. NM_001274604.1 → NP_001261533.1  Puratrophin-1-like, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261533.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PEF7
      Conserved Domains (3) summary
      cd13242
      Location:1518 → 1657
      PH_puratrophin-1; Puratrophin-1 pleckstrin homology (PH) domain
      pfam00169
      Location:1556 → 1649
      PH; PH domain
      pfam00621
      Location:1347 → 1526
      RhoGEF; RhoGEF domain

    3. NM_206295.3 → NP_996017.2  Puratrophin-1-like, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996017.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q29R11, Q7KU88
      Conserved Domains (3) summary
      cd13242
      Location:1048 → 1187
      PH_puratrophin-1; Puratrophin-1 pleckstrin homology (PH) domain
      pfam00169
      Location:1086 → 1179
      PH; PH domain
      pfam00621
      Location:877 → 1056
      RhoGEF; RhoGEF domain

    4. NM_206293.2 → NP_996015.1  Puratrophin-1-like, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996015.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KU87
      Conserved Domains (4) summary
      cd13242
      Location:492 → 631
      PH_puratrophin-1; Puratrophin-1 pleckstrin homology (PH) domain
      pfam00169
      Location:530 → 623
      PH; PH domain
      pfam00621
      Location:321 → 500
      RhoGEF; RhoGEF domain
      cl03493
      Location:5 → 159
      Alpha_TIF; Alpha trans-inducing protein (Alpha-TIF)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PEF7 M9PEF7
    Q7KU87 Q7KU87
    Q7KU88 Q7KU88
    Q7KU89 Q7KU89
    Q86NW6 Q86NW6
    Q8MSF1 Q8MSF1

    Gene LinkOut

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