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    CG10638 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39424, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG10638provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036290
    Locus tag
    Dmel_CG10638
    See related
    AllianceGenome:FB:FBgn0036290
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AKR; anon-WO0172774.89; AR; CG32101; Dmel\CG10638
    Summary
    Predicted to enable aldose reductase (NADPH) activity. Involved in fructose biosynthetic process and sorbitol biosynthetic process. Predicted to be active in cytosol. Is expressed in several structures, including Malpighian tubule primordium; adult head; embryonic/larval midgut primordium; ganglia; and gut section. Human ortholog(s) of this gene implicated in 46,XY sex reversal 8. Orthologous to human AKR1B10 (aldo-keto reductase family 1 member B10); AKR1B15 (aldo-keto reductase family 1 member B15); and AKR1C4 (aldo-keto reductase family 1 member C4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG10638 in Genome Data Viewer
    Location:
    69C3-69C4; 3-38 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (12498106..12501311, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (12491206..12494411, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45681 Neighboring gene antisense RNA:CR45682 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR43868 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene vihar

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Integrating protein-protein interaction networks with phenotypes reveals signs of interactions. Vinayagam A, et al. Nat Methods, 2014 Jan. PMID 24240319, Free PMC Article
    2. The polyol pathway is an evolutionarily conserved system for sensing glucose uptake. Sano H, et al. PLoS Biol, 2022 Jun. PMID 35687590, Free PMC Article
    3. Gene Expression as a Dosimeter in Irradiated Drosophila melanogaster. Shrestha S, et al. J Comput Biol, 2017 Dec. PMID 29035581, Free PMC Article
    4. SWI/SNF regulates the alternative processing of a specific subset of pre-mRNAs in Drosophila melanogaster. Waldholm J, et al. BMC Mol Biol, 2011 Nov 2. PMID 22047075, Free PMC Article
    5. Circulating fructose regulates a germline stem cell increase via gustatory receptor-mediated gut hormone secretion in mated Drosophila. Hoshino R, et al. Sci Adv, 2023 Feb 24. PMID 36827377, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables aldose reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aldose reductase (NADPH) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables aldose reductase (NADPH) activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in fructose biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in sorbitol biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG10638-PA
    CG10638-PB
    CG10638-PD
    aldo-keto reductase
    aldose reductase
    NP_001287050.1
    NP_729808.1
    NP_996068.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      12498106..12501311 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300121.1 → NP_001287050.1  uncharacterized protein Dmel_CG10638, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287050.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SXE8, Q9VTY2, Q9VTY3
      Conserved Domains (2) summary
      COG0656
      Location:5 → 302
      ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
      COG0667
      Location:5 → 297
      Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

    2. NM_168501.2 → NP_729808.1  uncharacterized protein Dmel_CG10638, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729808.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SXE8, Q9VTY2, Q9VTY3
      Related
      FBpp0088362
      Conserved Domains (2) summary
      COG0656
      Location:5 → 302
      ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
      COG0667
      Location:5 → 297
      Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

    3. NM_206346.3 → NP_996068.1  uncharacterized protein Dmel_CG10638, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996068.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4V4R8, Q8IQH2
      Conserved Domains (2) summary
      COG0656
      Location:5 → 299
      ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
      COG0667
      Location:5 → 284
      Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IQH2 Q8IQH2
    Q8SXE8 Q8SXE8
    Q9VTY2 Q9VTY2

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