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    CG12229 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39945, updated on 17-Dec-2024

    Summary

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    Official Symbol
    CG12229provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036723
    Locus tag
    Dmel_CG12229
    See related
    AllianceGenome:FB:FBgn0036723
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG12229
    Summary
    Predicted to enable pyruvate kinase activity. Predicted to be involved in canonical glycolysis and pyruvate biosynthetic process. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in spermatozoon. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG12229 in Genome Data Viewer
    Location:
    74C1-74C1; 3-45 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (17434472..17436431, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (17427572..17429531, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Golgin, RAB6 interacting Neighboring gene Coenzyme Q4 Neighboring gene fringe connection Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44565

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Developmental inhibition of miR-iab8-3p disrupts mushroom body neuron structure and adult learning ability. Busto GU, et al. Dev Biol, 2016 Nov 15. PMID 27634569, Free PMC Article
    2. Metabolomic analysis of Drosophila melanogaster larvae lacking pyruvate kinase. Heidarian Y, et al. G3 (Bethesda), 2023 Dec 29. PMID 37792629, Free PMC Article
    3. Translational profiling of clock cells reveals circadianly synchronized protein synthesis. Huang Y, et al. PLoS Biol, 2013 Nov. PMID 24348200, Free PMC Article
    4. Mechanisms underlying hypoxia tolerance in Drosophila melanogaster: hairy as a metabolic switch. Zhou D, et al. PLoS Genet, 2008 Oct. PMID 18927626, Free PMC Article
    5. A Glio-Protective Role of mir-263a by Tuning Sensitivity to Glutamate. Aw SS, et al. Cell Rep, 2017 May 30. PMID 28564598

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyruvate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pyruvate kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyruvate kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in canonical glycolysis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in glycolytic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycolytic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycolytic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in pyruvate biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG12229-PA
    pyruvate kinase
    NP_648980.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      17434472..17436431 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140723.1 → NP_648980.1  uncharacterized protein Dmel_CG12229 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648980.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VVH0
      Related
      FBpp0074988, FBtr0075226
      Conserved Domains (2) summary
      TIGR01064
      Location:103 → 530
      pyruv_kin; pyruvate kinase
      cl23794
      Location:126 → 530
      Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VVH0 Q9VVH0

    Gene LinkOut

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