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    COX7AL Cytochrome c oxidase subunit 7A-like [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40995, updated on 9-Dec-2024

    Summary

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    Official Symbol
    COX7ALprovided by FlyBase
    Official Full Name
    Cytochrome c oxidase subunit 7A-likeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037579
    Locus tag
    Dmel_CG18193
    See related
    AllianceGenome:FB:FBgn0037579
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG18193; COXJ; COXK; Dmel\CG18193; VIIa
    Summary
    Predicted to be involved in mitochondrial respirasome assembly and regulation of oxidative phosphorylation. Predicted to be part of respiratory chain complex. Is expressed in adult head and spermatozoon. Orthologous to several human genes including COX7A1 (cytochrome c oxidase subunit 7A1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See COX7AL in Genome Data Viewer
    Location:
    84F13-84F13; 3-48 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (8343669..8344310)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (4169391..4170032)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Cytochrome c oxidase subunit 7A Neighboring gene ADP ribosylation factor-like 2 Neighboring gene Polynucleotide kinase 3'-phosphatase Neighboring gene Dipeptidyl aminopeptidase III Neighboring gene uncharacterized protein Neighboring gene mir-9380 stem loop

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Variation in Mitochondria-Derived Transcript Levels Associated With DDT Resistance in the 91-R Strain of Drosophila melanogaster (Diptera: Drosophilidae). Steele LD, et al. J Insect Sci, 2018 Nov 1. PMID 30383265, Free PMC Article
    2. CG7630 is the Drosophila melanogaster homolog of the cytochrome c oxidase subunit COX7B. Brischigliaro M, et al. EMBO Rep, 2022 Aug 3. PMID 35699132, Free PMC Article
    3. The cyclope gene of Drosophila encodes a cytochrome c oxidase subunit VIc homolog. Szuplewski S, et al. Genetics, 2001 Aug. PMID 11514451, Free PMC Article
    4. Analyses of nuclearly encoded mitochondrial genes suggest gene duplication as a mechanism for resolving intralocus sexually antagonistic conflict in Drosophila. Gallach M, et al. Genome Biol Evol, 2010. PMID 21037198, Free PMC Article
    5. Identification of sphingolipid metabolites that induce obesity via misregulation of appetite, caloric intake and fat storage in Drosophila. Walls SM Jr, et al. PLoS Genet, 2013. PMID 24339790, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in mitochondrial electron transport, cytochrome c to oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial respirasome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of oxidative phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of respiratory chain complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex IV IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of respiratory chain complex IV ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome c oxidase subunit 7A-like
    Names
    CG18193-PA
    COX7AL-PA
    cytochrome c oxidase polypeptide VIIa

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      8343669..8344310
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141536.3 → NP_649793.1  cytochrome c oxidase subunit 7A-like [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649793.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VHR9
      Related
      FBpp0081329
      Conserved Domains (1) summary
      cd00928
      Location:51 → 105
      Cyt_c_Oxidase_VIIa; Cytochrome c oxidase subunit VIIa. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VHR9 Q9VHR9

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