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    CG15923 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42443, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG15923provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038814
    Locus tag
    Dmel_CG15923
    See related
    AllianceGenome:FB:FBgn0038814
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG15923
    Summary
    Predicted to be involved in cilium assembly. Predicted to be part of MKS complex. Predicted to be active in ciliary transition zone. Is expressed in adult brain. Human ortholog(s) of this gene implicated in several diseases, including Bardet-Biedl syndrome (multiple); COACH syndrome; Joubert syndrome 6; Meckel syndrome 3; and nephronophthisis (multiple). Orthologous to human TMEM67 (transmembrane protein 67). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG15923 in Genome Data Viewer
    Location:
    92F3-92F3; 3-69 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (20611251..20616901, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (16436973..16442623, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Signal recognition particle 72 Neighboring gene Pseudouridine synthase 1 Neighboring gene bonus Neighboring gene transfer RNA:Leucine-TAA 1-1 Neighboring gene uncharacterized protein Neighboring gene Hairless

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Lrrk regulates the dynamic profile of dendritic Golgi outposts through the golgin Lava lamp. Lin CH, et al. J Cell Biol, 2015 Aug 3. PMID 26216903, Free PMC Article
    2. A migrating ciliary gate compartmentalizes the site of axoneme assembly in Drosophila spermatids. Basiri ML, et al. Curr Biol, 2014 Nov 17. PMID 25447994, Free PMC Article
    3. Components of Intraflagellar Transport Complex A Function Independently of the Cilium to Regulate Canonical Wnt Signaling in Drosophila. Balmer S, et al. Dev Cell, 2015 Sep 28. PMID 26364750, Free PMC Article
    4. A new in vivo model of pantothenate kinase-associated neurodegeneration reveals a surprising role for transcriptional regulation in pathogenesis. Pandey V, et al. Front Cell Neurosci, 2013. PMID 24058333, Free PMC Article
    5. Loss of the endoplasmic reticulum protein Tmem208 affects cell polarity, development, and viability. Dutta D, et al. Proc Natl Acad Sci U S A, 2024 Feb 27. PMID 38381787, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cilium assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of MKS complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in ciliary transition zone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG15923-PB
    CG15923-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      20611251..20616901 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001104376.3 → NP_001097846.1  uncharacterized protein Dmel_CG15923, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097846.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NN50, Q9VDK3
      Conserved Domains (1) summary
      pfam09773
      Location:173 → 967
      Meckelin; Meckelin (Transmembrane protein 67)

    2. NM_001275840.1 → NP_001262769.1  uncharacterized protein Dmel_CG15923, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262769.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KGJ7
      Conserved Domains (1) summary
      pfam09773
      Location:173 → 967
      Meckelin; Meckelin (Transmembrane protein 67)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KGJ7 A0A0B4KGJ7
    Q9VDK3 Q9VDK3

    Gene LinkOut

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