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    CG15528 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43575, updated on 27-Dec-2024

    Summary

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    Official Symbol
    CG15528provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039742
    Locus tag
    Dmel_CG15528
    See related
    AllianceGenome:FB:FBgn0039742
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG15528
    Summary
    Predicted to be involved in protein dephosphorylation. Is expressed in organism. Used to study chromosome 17q12 deletion syndrome. Orthologous to several human genes including DUSP14 (dual specificity phosphatase 14). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG15528 in Genome Data Viewer
    Location:
    99D3-99D3; 3-100 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (30048635..30052112, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (25874357..25877834, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Serendipity delta Neighboring gene Ribosomal protein L32 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44046 Neighboring gene JIL-1 anchoring and stabilizing protein Neighboring gene spindle A Neighboring gene Ribonuclease P/MRP subunit p14 b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Drosophila-centric view of protein tyrosine phosphatases. Hatzihristidis T, et al. FEBS Lett, 2015 Apr 13. PMID 25771859
    2. Drosophila models of pathogenic copy-number variant genes show global and non-neuronal defects during development. Yusuff T, et al. PLoS Genet, 2020 Jun. PMID 32579612, Free PMC Article
    3. Ectopic expression of S28A-mutated Histone H3 modulates longevity, stress resistance and cardiac function in Drosophila. Joos JP, et al. Sci Rep, 2018 Feb 13. PMID 29440697, Free PMC Article
    4. Amyloid fibril proteomics of AD brains reveals modifiers of aggregation and toxicity. Upadhyay A, et al. Mol Neurodegener, 2023 Sep 14. PMID 37710351, Free PMC Article
    5. Genetic Architecture of Abdominal Pigmentation in Drosophila melanogaster. Dembeck LM, et al. PLoS Genet, 2015 May. PMID 25933381, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG15528-PB
    MKP-like
    NP_651767.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      30048635..30052112 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143510.2 → NP_651767.2  uncharacterized protein Dmel_CG15528 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651767.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      B3DNI0, Q9VAB0
      Conserved Domains (1) summary
      cd00127
      Location:43 → 181
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VAB0 Q9VAB0

    Gene LinkOut

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