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    GNBP2 Gram-negative bacteria binding protein 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40033, updated on 9-Dec-2024

    Summary

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    Official Symbol
    GNBP2provided by FlyBase
    Official Full Name
    Gram-negative bacteria binding protein 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0040322
    Locus tag
    Dmel_CG4144
    See related
    AllianceGenome:FB:FBgn0040322
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4144; DGNBP-2; Dmel\CG4144; GNBP; gnbp2
    Summary
    Enables (1->3)-beta-D-glucan binding activity and lipopolysaccharide binding activity. Predicted to be involved in pattern recognition receptor signaling pathway. Predicted to be located in extracellular region. Is expressed in embryonic/larval fat body and organism. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See GNBP2 in Genome Data Viewer
    Location:
    75D6-75D6; 3-45 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (18673474..18675413, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (18666574..18668513, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Caprin Neighboring gene Gram-negative bacteria binding protein 1 Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolution of the βGRP/GNBP/β-1,3-glucanase family of insects. Hughes AL. Immunogenetics, 2012 Jul. PMID 22410636
    2. Effects of solutes on solubilization and refolding of proteins from inclusion bodies with high hydrostatic pressure. Lee SH, et al. Protein Sci, 2006 Feb. PMID 16385003, Free PMC Article
    3. O-GlcNAcylation of boundary element associated factor (BEAF 32) in Drosophila melanogaster correlates with active histone marks at the promoters of its target genes. De D, et al. Nucleus, 2018 Jan 1. PMID 28910574, Free PMC Article
    4. Gram-negative bacteria-binding protein, a pattern recognition receptor for lipopolysaccharide and beta-1,3-glucan that mediates the signaling for the induction of innate immune genes in Drosophila melanogaster cells. Kim YS, et al. J Biol Chem, 2000 Oct 20. PMID 10827089
    5. Genotype and gene expression associations with immune function in Drosophila. Sackton TB, et al. PLoS Genet, 2010 Jan. PMID 20066029, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables (1->3)-beta-D-glucan binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT enables beta-glucanase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT enables hydrolase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    enables lipopolysaccharide binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pattern recognition receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in innate immune response-activating signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in pattern recognition receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of innate immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    Gram-negative bacteria binding protein 2
    Names
    CG4144-PA
    CG4144-PB
    CG4144-PD
    GNBP2-PA
    GNBP2-PB
    GNBP2-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      18673474..18675413 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168772.2 → NP_730351.1  Gram-negative bacteria binding protein 2, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730351.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VVR4
      Related
      FBpp0074863
      Conserved Domains (2) summary
      cd02179
      Location:114 → 409
      GH16_beta_GRP; beta-1,3-glucan recognition protein, member of glycosyl hydrolase family 16
      pfam15886
      Location:14 → 69
      CBM39; Carbohydrate binding domain (family 32)

    2. NM_168771.2 → NP_730350.1  Gram-negative bacteria binding protein 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730350.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VVR4
      Related
      FBpp0074862
      Conserved Domains (2) summary
      cd02179
      Location:136 → 431
      GH16_beta_GRP; beta-1,3-glucan recognition protein, member of glycosyl hydrolase family 16
      pfam15886
      Location:2 → 91
      CBM39; Carbohydrate binding domain (family 32)

    3. NM_079417.3 → NP_524141.1  Gram-negative bacteria binding protein 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524141.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0ZWZ5, A0ZWZ8, A0ZX11, A0ZX12, A0ZX13, A0ZX39, A0ZX40, A0ZX41, A0ZX42, Q8IQT6, Q8IQT7, Q95U68, Q9NHA9, Q9VVR4
      UniProtKB/TrEMBL
      C6TP47
      Related
      FBpp0074861
      Conserved Domains (2) summary
      cd02179
      Location:165 → 460
      GH16_beta_GRP; beta-1,3-glucan recognition protein, member of glycosyl hydrolase family 16
      pfam15886
      Location:22 → 120
      CBM39; Carbohydrate binding domain (family 32)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VVR4.3 Q9VVR4

    Gene LinkOut

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