RNaseX25 Ribonuclease X25 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: RNaseX25provided by FlyBase
Official Full Name: Ribonuclease X25provided by FlyBase
Primary source: FLYBASE:FBgn0010406
Locus tag: Dmel_CG8194
See related: AllianceGenome:FB:FBgn0010406
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG8194; Dmel\CG8194; DmRNase-66B; DmRNase-X25; RNase X25; Rny1
Summary: Predicted to enable RNA endonuclease activity. Involved in sexual reproduction. Predicted to be located in extracellular space. Predicted to be active in extracellular region. Is expressed in several structures, including adult heart; antennal anlage; antennal primordium; central brain anlage; and head epidermis primordium. Human ortholog(s) of this gene implicated in several diseases, including Lynch syndrome; RNASET2-deficient cystic leukoencephalopathy; colorectal cancer (multiple); lung cancer; and mismatch repair cancer syndrome. Orthologous to human RNASET2 (ribonuclease T2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (7970588..7972449)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (7963688..7965549)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

RNase X25 expression is elevated in response to nutritional stresses; consistent with the hypothesis that this enzyme has a housekeeping role in recycling RNA.
Title: Phylogenetic analyses and characterization of RNase X25 from Drosophila melanogaster suggest a conserved housekeeping role and additional functions for RNase T2 enzymes in protostomes.

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Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA endonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables ribonuclease T2 activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in RNA catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in RNA catabolic process	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in sexual reproduction	HEP more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISM Inferred from Sequence Model more info	PubMed