U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    SpdS Spermidine Synthase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41167, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    SpdSprovided by FlyBase
    Official Full Name
    Spermidine Synthaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037723
    Locus tag
    Dmel_CG8327
    See related
    AllianceGenome:FB:FBgn0037723
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8327; Dmel\CG8327; spds; Spds
    Summary
    Predicted to enable spermidine synthase activity. Predicted to be involved in spermidine biosynthetic process. Predicted to be active in cytosol. Is expressed in several structures, including adult head; embryonic/larval fat body; embryonic/larval midgut; embryonic/larval midgut primordium; and posterior endoderm. Orthologous to human SRM (spermidine synthase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See SpdS in Genome Data Viewer
    Location:
    85E1-85E2; 3-49 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9631641..9633673)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5457363..5459395)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene stable intronic sequence RNA CR46357 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45053 Neighboring gene Calreticulin Neighboring gene Sex comb on midleg Neighboring gene Diuretic hormone 44 Neighboring gene Frost Neighboring gene pseudo Neighboring gene Dynein heavy chain 1

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The Role of Spermidine Synthase (SpdS) and Spermine Synthase (Sms) in Regulating Triglyceride Storage in Drosophila. Morales TS, et al. Med Sci (Basel), 2021 May 2. PMID 34063217, Free PMC Article
    2. Chronic sleep loss sensitizes Drosophila melanogaster to nitrogen stress. Bedont JL, et al. Curr Biol, 2023 Apr 24. PMID 36965479, Free PMC Article
    3. Spatiotemporal patterning of polyamines in Drosophila development. Burnette M, et al. Amino Acids, 2015 Dec. PMID 26386564
    4. Upregulation of ribosome biogenesis via canonical E-boxes is required for Myc-driven proliferation. Zielke N, et al. Dev Cell, 2022 Apr 25. PMID 35472319
    5. Chromosomal Instability Causes Sensitivity to Polyamines and One-Carbon Metabolism. Islam A, et al. Metabolites, 2023 May 9. PMID 37233683, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Role of Spermidine Synthase (SpdS) and Spermine Synthase (Sms) in Regulating Triglyceride Storage in Drosophila.
      Title: The Role of Spermidine Synthase (SpdS) and Spermine Synthase (Sms) in Regulating Triglyceride Storage in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables spermidine synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in polyamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermidine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    spermidine synthase
    Names
    CG8327-PA
    CG8327-PB
    CG8327-PC
    SpdS-PA
    SpdS-PB
    SpdS-PC
    NP_001247005.1
    NP_649921.1
    NP_731384.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      9631641..9633673
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169298.3 → NP_731384.1  spermidine synthase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731384.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86P04, Q9VHA1
      Related
      FBpp0081556
      Conserved Domains (1) summary
      cl17173
      Location:1 → 283
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    2. NM_141664.5 → NP_649921.1  spermidine synthase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649921.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95TE9, Q9VHA2
      Related
      FBpp0081557
      Conserved Domains (1) summary
      cl17173
      Location:1 → 214
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    3. NM_001260076.2 → NP_001247005.1  spermidine synthase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247005.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86P04, Q9VHA1
      Conserved Domains (1) summary
      cl17173
      Location:1 → 283
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86P04 Q86P04
    Q9VHA1 Q9VHA1
    Q9VHA2 Q9VHA2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous