Mpc1 Mitochondrial pyruvate carrier [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Mpc1provided by FlyBase
Official Full Name: Mitochondrial pyruvate carrierprovided by FlyBase
Primary source: FLYBASE:FBgn0038662
Locus tag: Dmel_CG14290
See related: AllianceGenome:FB:FBgn0038662
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG14290; Dmel\CG14290; dMPC1; MPC; MPC1
Summary: Predicted to enable pyruvate transmembrane transporter activity. Involved in pyruvate metabolic process. Located in mitochondrion. Is expressed in adult head and adult insulin secreting cell of pars intercerebralis. Used to study intestinal cancer and mitochondrial pyruvate carrier deficiency. Human ortholog(s) of this gene implicated in mitochondrial pyruvate carrier deficiency. Orthologous to several human genes including MPC1 (mitochondrial pyruvate carrier 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (18926996..18928659, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (14752718..14754381, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables pyruvate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables pyruvate transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in mitochondrial pyruvate transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial pyruvate transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial pyruvate transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in pyruvate metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in mitochondrial inner membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed

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The following sections contain reference sequences that belong to a specific genome build. Explain