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    Tsp42El Tetraspanin 42El [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35622, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tsp42Elprovided by FlyBase
    Official Full Name
    Tetraspanin 42Elprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033134
    Locus tag
    Dmel_CG12840
    See related
    AllianceGenome:FB:FBgn0033134
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Posey244; CG12840; Dm.Tsp42El; Dmel\CG12840; Tsp42E1
    Summary
    Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including adult head; adult heart; embryonic esophagus; embryonic head epidermis; and embryonic/larval dorsal vessel. Orthologous to human TSPAN3 (tetraspanin 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Tsp42El in Genome Data Viewer
    Location:
    42E5-42E5; 2-55 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7045769..7048538)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (2933274..2936043)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Tetraspanin 42Ej Neighboring gene Tetraspanin 42Ek Neighboring gene late bloomer Neighboring gene Tetraspanin 42En

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic dissociation of ethanol sensitivity and memory formation in Drosophila melanogaster. LaFerriere H, et al. Genetics, 2008 Apr. PMID 18430923, Free PMC Article
    2. Analysis of cell surface proteome changes via label-free, quantitative mass spectrometry. Schiess R, et al. Mol Cell Proteomics, 2009 Apr. PMID 19036722, Free PMC Article
    3. The transcription factor Ets21C drives tumor growth by cooperating with AP-1. Toggweiler J, et al. Sci Rep, 2016 Oct 7. PMID 27713480, Free PMC Article
    4. A Drosophila DEG/ENaC channel subunit is required for male response to female pheromones. Lin H, et al. Proc Natl Acad Sci U S A, 2005 Sep 6. PMID 16129837, Free PMC Article
    5. Involvement of CD9 and PDGFR in migration is evolutionarily conserved from Drosophila glia to human glioma. Jeibmann A, et al. J Neurooncol, 2015 Sep. PMID 26224160

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 7046804-7047106 mobile_element_type = transposon:INE-1{}3009

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tetraspanin 42El
    Names
    CG12840-PA
    Tsp42El-PA
    tetraspanin 42E
    tetraspanin at 42El

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      7045769..7048538
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078914.3 → NP_523638.1  tetraspanin 42El [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523638.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K527
      Related
      FBpp0088103
      Conserved Domains (2) summary
      cd03127
      Location:94 → 178
      tetraspanin_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the ...
      pfam00335
      Location:7 → 196
      Tetraspannin; Tetraspanin family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K527 Q7K527

    Gene LinkOut

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