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    ERR estrogen-related receptor [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38912, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ERRprovided by FlyBase
    Official Full Name
    estrogen-related receptorprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035849
    Locus tag
    Dmel_CG7404
    See related
    AllianceGenome:FB:FBgn0035849
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7404; dERR; Derr; Dmel\CG7404; NR3B4
    Summary
    Predicted to enable estrogen response element binding activity and nuclear receptor activity. Involved in regulation of transcription by RNA polymerase II and spermatogenesis. Predicted to be located in chromatin. Predicted to be active in nucleus. Is expressed in anterior midgut primordium; embryonic midgut chamber; embryonic/larval midgut; organism; and posterior midgut primordium. Used to study azoospermia and cancer. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 35. Orthologous to several human genes including ESRRA (estrogen related receptor alpha). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See ERR in Genome Data Viewer
    Location:
    66B11-66B11; 3-22 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (8183361..8186671, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (8176461..8179771, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene N-myristoyl transferase Neighboring gene methuselah-like 7 Neighboring gene antisense RNA:CR45869 Neighboring gene UDP-xylose synthase Neighboring gene antisense RNA:CR45870 Neighboring gene Autophagy-related 18a Neighboring gene uncharacterized protein Neighboring gene Mediator complex subunit 24

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A triple mutant of the Drosophila ERR confers ligand-induced suppression of activity. Ostberg T, et al. Biochemistry, 2003 Jun 3. PMID 12767224
    2. Developmental neurotoxic effects of bisphenol A and its derivatives in Drosophila melanogaster. Wang J, et al. Ecotoxicol Environ Saf, 2023 Jul 15. PMID 37269611
    3. Identification of glucocorticoid receptor in Drosophila melanogaster. Bartolo G, et al. BMC Microbiol, 2020 Jun 15. PMID 32539689, Free PMC Article
    4. The Drosophila nuclear receptors EcR and ERR jointly regulate the expression of genes involved in carbohydrate metabolism. Kovalenko EV, et al. Insect Biochem Mol Biol, 2019 Sep. PMID 31295549
    5. Drosophila estrogen-related receptor directs a transcriptional switch that supports adult glycolysis and lipogenesis. Beebe K, et al. Genes Dev, 2020 May 1. PMID 32165409, Free PMC Article

    See all (101) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification of glucocorticoid receptor in Drosophila melanogaster.
      Title: Identification of glucocorticoid receptor in Drosophila melanogaster.
    2. Drosophila estrogen-related receptor directs a transcriptional switch that supports adult glycolysis and lipogenesis.
      Title: Drosophila estrogen-related receptor directs a transcriptional switch that supports adult glycolysis and lipogenesis.
    3. These findings add newer dimensions to the functions envisaged for ERR and provide the foundation for deciphering the relevance of orphan nuclear receptors in ciliopathies and testicular dysgenesis.
      Title: Estrogen related receptor is required for the testicular development and for the normal sperm axoneme/mitochondrial derivatives in Drosophila males.
    4. Expression levels of estrogen-related receptor gene (ERR), ecdysone receptor gene (EcR) and Yolk protein receptor gene (YPR) were significantly changed by ethylparaben treatment. Female fruit flies are more sensitive to EP than males.
      Title: Ethylparaben affects lifespan, fecundity, and the expression levels of ERR, EcR and YPR in Drosophila melanogaster.
    5. These results indicate that competent hypoxic responses arise from complex interactions between HIF-dependent and -independent mechanisms, and that dERR plays a central role in both of these programs.
      Title: HIF- and non-HIF-regulated hypoxic responses require the estrogen-related receptor in Drosophila melanogaster.
    6. The estrogen-related receptor plays a central role in carbohydrate metabolism, demonstrates that a proliferative metabolic program is used in normal developmental growth
      Title: The Drosophila estrogen-related receptor directs a metabolic switch that supports developmental growth.
    7. characterization of ligand binding pocket of ERR
      Title: A triple mutant of the Drosophila ERR confers ligand-induced suppression of activity.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables estrogen response element binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear receptor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables nuclear steroid receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables steroid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    estrogen-related receptor
    Names
    CG7404-PA
    CG7404-PB
    ERR-PA
    ERR-PB
    Estrogen-Related receptor
    estrogen receptor
    estrogen related receptor

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      8183361..8186671 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168258.3 → NP_729340.1  estrogen-related receptor, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729340.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VSE9
      Related
      FBpp0076447
      Conserved Domains (2) summary
      cd07170
      Location:109 → 205
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
      cl11397
      Location:225 → 481
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

    2. NM_139926.3 → NP_648183.3  estrogen-related receptor, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648183.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8WS79
      Related
      FBpp0076448
      Conserved Domains (2) summary
      cd07170
      Location:121 → 217
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
      cl11397
      Location:237 → 493
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8WS79 Q8WS79
    Q9VSE9 Q9VSE9

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