Skp2 S-phase kinase-associated protein 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Skp2provided by FlyBase
Official Full Name: S-phase kinase-associated protein 2provided by FlyBase
Primary source: FLYBASE:FBgn0037236
Locus tag: Dmel_CG9772
See related: AllianceGenome:FB:FBgn0037236
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 153298_at; CG9772; Dmel\CG9772; dSkp2; F-box; FBXL1; SKP2
Summary: Involved in several processes, including compound eye development; endomitotic cell cycle; and regulation of protein stability. Part of SCF ubiquitin ligase complex. Is expressed in several structures, including anterior endoderm; central brain primordium; egg chamber; embryonic/larval midgut primordium; and follicle cell. Human ortholog(s) of this gene implicated in prostate carcinoma. Orthologous to human SKP2 (S-phase kinase associated protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (4334879..4337674, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (160601..163396, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

The Drosophila Skp2 regulates cell proliferation by targeting Dacapo for degradation.
Title: The Drosophila F-box protein dSkp2 regulates cell proliferation by targeting Dacapo for degradation.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

Process	Evidence Code	Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	ISM Inferred from Sequence Model more info
involved_in compound eye development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endomitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein stability	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wing disc development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of SCF ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SCF ubiquitin ligase complex	IDA Inferred from Direct Assay more info	PubMed
part_of SCF ubiquitin ligase complex	ISM Inferred from Sequence Model more info

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The following sections contain reference sequences that belong to a specific genome build. Explain