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    Droj2 DnaJ-like-2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41646, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Droj2provided by FlyBase
    Official Full Name
    DnaJ-like-2provided by FlyBase
    Primary source
    FLYBASE:FBgn0038145
    Locus tag
    Dmel_CG8863
    See related
    AllianceGenome:FB:FBgn0038145
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.404; CG8863; Dmel\CG8863; DnaJL2A; DROJ2; Hsp40
    Summary
    Predicted to enable protein-folding chaperone binding activity. Predicted to be involved in protein refolding. Predicted to be active in cytosol. Is expressed in adult head; adult heart; and organism. Orthologous to human DNAJA1 (DnaJ heat shock protein family (Hsp40) member A1) and DNAJA4 (DnaJ heat shock protein family (Hsp40) member A4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Droj2 in Genome Data Viewer
    Location:
    87E8-87E8; 3-53 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (13382106..13385283)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (9207828..9211005)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44138 Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein S21 Neighboring gene uncharacterized protein Neighboring gene CCHamide-2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Droj2 Facilitates Somatosensory Neurite Sculpting via GTP-Binding Protein Arf102F in Drosophila. Rui M, et al. Int J Mol Sci, 2023 Aug 25. PMID 37686022, Free PMC Article
    2. The HSP40 chaperone Ydj1 drives amyloid beta 42 toxicity. Ring J, et al. EMBO Mol Med, 2022 May 9. PMID 35373908, Free PMC Article
    3. Sex-lethal promotes nuclear retention of msl2 mRNA via interactions with the STAR protein HOW. Graindorge A, et al. Genes Dev, 2013 Jun 15. PMID 23788626, Free PMC Article
    4. The Role of the Phylogenetically Conserved Cochaperone Protein Droj2/DNAJA3 in NF-κB Signaling. Momiuchi Y, et al. J Biol Chem, 2015 Sep 25. PMID 26245905, Free PMC Article
    5. Conformational Activation of Argonaute by Distinct yet Coordinated Actions of the Hsp70 and Hsp90 Chaperone Systems. Tsuboyama K, et al. Mol Cell, 2018 May 17. PMID 29775584

    See all (74) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Droj2 Facilitates Somatosensory Neurite Sculpting via GTP-Binding Protein Arf102F in Drosophila.
      Title: Droj2 Facilitates Somatosensory Neurite Sculpting via GTP-Binding Protein Arf102F in Drosophila.
    2. The Role of the Phylogenetically Conserved Cochaperone Protein Droj2/DNAJA3 in NF-kappaB Signaling.
      Title: The Role of the Phylogenetically Conserved Cochaperone Protein Droj2/DNAJA3 in NF-κB Signaling.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Hsp70 protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-folding chaperone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to heat IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    DnaJ-like-2
    Names
    CG8863-PA
    CG8863-PB
    CG8863-PC
    CG8863-PD
    CG8863-PE
    DnaJ-like-2 chaperone
    Droj2-PA
    Droj2-PB
    Droj2-PC
    Droj2-PD
    Droj2-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      13382106..13385283
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142026.3 → NP_650283.1  DnaJ-like-2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650283.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VFV9
      Related
      FBpp0082219
      Conserved Domains (4) summary
      cd10719
      Location:140 → 206
      DnaJ_zf; Zinc finger domain of DnaJ and HSP40
      cd10747
      Location:112 → 336
      DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
      PTZ00037
      Location:2 → 398
      PTZ00037; DnaJ_C chaperone protein; Provisional
      pfam00226
      Location:7 → 65
      DnaJ; DnaJ domain

    2. NM_169522.2 → NP_731807.1  DnaJ-like-2, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731807.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VFV9
      Related
      FBpp0082223
      Conserved Domains (4) summary
      cd10719
      Location:140 → 206
      DnaJ_zf; Zinc finger domain of DnaJ and HSP40
      cd10747
      Location:112 → 336
      DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
      PTZ00037
      Location:2 → 398
      PTZ00037; DnaJ_C chaperone protein; Provisional
      pfam00226
      Location:7 → 65
      DnaJ; DnaJ domain

    3. NM_169519.2 → NP_731804.1  DnaJ-like-2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731804.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VFV9
      Related
      FBpp0082220
      Conserved Domains (4) summary
      cd10719
      Location:140 → 206
      DnaJ_zf; Zinc finger domain of DnaJ and HSP40
      cd10747
      Location:112 → 336
      DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
      PTZ00037
      Location:2 → 398
      PTZ00037; DnaJ_C chaperone protein; Provisional
      pfam00226
      Location:7 → 65
      DnaJ; DnaJ domain

    4. NM_169520.2 → NP_731805.1  DnaJ-like-2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731805.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VFV9
      Related
      FBpp0082221
      Conserved Domains (4) summary
      cd10719
      Location:140 → 206
      DnaJ_zf; Zinc finger domain of DnaJ and HSP40
      cd10747
      Location:112 → 336
      DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
      PTZ00037
      Location:2 → 398
      PTZ00037; DnaJ_C chaperone protein; Provisional
      pfam00226
      Location:7 → 65
      DnaJ; DnaJ domain

    5. NM_169521.2 → NP_731806.1  DnaJ-like-2, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731806.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VFV9
      Related
      FBpp0082222
      Conserved Domains (4) summary
      cd10719
      Location:140 → 206
      DnaJ_zf; Zinc finger domain of DnaJ and HSP40
      cd10747
      Location:112 → 336
      DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
      PTZ00037
      Location:2 → 398
      PTZ00037; DnaJ_C chaperone protein; Provisional
      pfam00226
      Location:7 → 65
      DnaJ; DnaJ domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VFV9 Q9VFV9

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