ttm50 tiny tim 50 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: ttm50provided by FlyBase
Official Full Name: tiny tim 50provided by FlyBase
Primary source: FLYBASE:FBgn0250874
Locus tag: Dmel_CG2713
See related: AllianceGenome:FB:FBgn0250874
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 17944223; CG2713; Dmel\CG2713; EG:95B7.3; Gp99; i238; i90; Ttm50
Summary: Enables cysteine-type endopeptidase activator activity. Involved in mitochondrion organization; protein localization to Golgi apparatus; and protein localization to endoplasmic reticulum. Located in mitochondrion. Is active in Golgi apparatus; endoplasmic reticulum; and mitochondrial inner membrane. Is expressed in several structures, including embryonic/larval midgut primordium; gut section; larval muscle cell; mesoderm; and visceral muscle primordium. Human ortholog(s) of this gene implicated in 3-methylglutaconic aciduria type 9. Orthologous to human TIMM50 (translocase of inner mitochondrial membrane 50). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 3B3-3B3; 1-1.5 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (2730077..2732190, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (2624250..2626223, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ttm50 facilitates calpain activation by anchoring it to calcium stores and increasing its sensitivity to calcium.
Title: Ttm50 facilitates calpain activation by anchoring it to calcium stores and increasing its sensitivity to calcium.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein tyrosine phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in mitochondrial membrane organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrion organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein dephosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein import into mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
involved_in protein localization to endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
part_of TIM23 mitochondrial import inner membrane translocase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of TIM23 mitochondrial import inner membrane translocase complex	ISS Inferred from Sequence or Structural Similarity more info
part_of TIM23 mitochondrial import inner membrane translocase complex	TAS Traceable Author Statement more info	PubMed
is_active_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrial inner membrane	EXP Inferred from Experiment more info	PubMed
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: tiny tim 50

Names: CG2713-PA; CG2713-PB; Gp99; ttm50-PA; ttm50-PB

NP_001303557.1

EC 3.1.3.16

EC 3.1.3.48

NP_570027.1

EC 3.1.3.16

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

2730077..2732190 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001316628.1 → NP_001303557.1 tiny tim 50, isoform B [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

O76907, Q8SZT0, Q9W4V8

UniProtKB/TrEMBL

A0A0S0X8K7

Conserved Domains (1) summary

smart00577
Location:227 → 355

CPDc; catalytic domain of ctd-like phosphatases
NM_130671.3 → NP_570027.1 tiny tim 50, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_570027.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O76907, Q8SZT0, Q9W4V8

UniProtKB/TrEMBL

A0A0S0X8K7

Related

FBpp0070474

Conserved Domains (1) summary

smart00577
Location:227 → 355

CPDc; catalytic domain of ctd-like phosphatases