UGP UDP-glucose pyrophosphorylase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: UGPprovided by FlyBase
Official Full Name: UDP-glucose pyrophosphorylaseprovided by FlyBase
Primary source: FLYBASE:FBgn0035978
Locus tag: Dmel_CG4347
See related: AllianceGenome:FB:FBgn0035978
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG4347; Dmel\CG4347; dUGP; UDPGPP; UGPase
Summary: Enables UTP:glucose-1-phosphate uridylyltransferase activity. Involved in UDP-glucose metabolic process and response to hyperoxia. Located in cytosol. Is expressed in several structures, including adult brain; adult brain cell body rind; adult head; germline cell; and larval somatic muscle cell. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 83. Orthologous to human UGP2 (UDP-glucose pyrophosphorylase 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 67B1-67B2; 3-29 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (9350867..9358935, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (9343967..9352035, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables UTP:glucose-1-phosphate uridylyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables UTP:glucose-1-phosphate uridylyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables UTP:glucose-1-phosphate uridylyltransferase activity	IEA Inferred from Electronic Annotation more info
enables UTP:glucose-1-phosphate uridylyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in UDP-alpha-D-glucose metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in UDP-alpha-D-glucose metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in UDP-alpha-D-glucose metabolic process	IEA Inferred from Electronic Annotation more info
involved_in UDP-alpha-D-glucose metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in glycogen biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in glycogen metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to hyperoxia	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	HDA more info	PubMed

General protein information

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Preferred Names: UDP-glucose pyrophosphorylase

Names: CG4347-PA; CG4347-PC; CG4347-PD; CG4347-PE; UGP-PA; UGP-PC; UGP-PD; UGP-PE; UTP-G-1-P uridyiyltransferase; uridine diphosphate-glucose pyrophosphorylase

NP_001163399.1

EC 2.7.7.9

NP_001163400.1

EC 2.7.7.9

NP_648300.3

EC 2.7.7.9

NP_729469.2

EC 2.7.7.9

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

9350867..9358935 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001169929.2 → NP_001163400.1 UDP-glucose pyrophosphorylase, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163400.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JI91, E8NH18

Conserved Domains (1) summary

pfam01704
Location:68 → 483

UDPGP; UTP--glucose-1-phosphate uridylyltransferase
NM_140043.5 → NP_648300.3 UDP-glucose pyrophosphorylase, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_648300.3

Status: REVIEWED

UniProtKB/TrEMBL

E8NH18, Q8T0B8, Q9VSW1

Conserved Domains (1) summary

pfam01704
Location:68 → 485

UDPGP; UTP--glucose-1-phosphate uridylyltransferase
NM_001169928.2 → NP_001163399.1 UDP-glucose pyrophosphorylase, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163399.1

Status: REVIEWED

UniProtKB/TrEMBL

A5XCL5, E8NH18

Conserved Domains (1) summary

pfam01704
Location:61 → 476

UDPGP; UTP--glucose-1-phosphate uridylyltransferase
NM_168325.4 → NP_729469.2 UDP-glucose pyrophosphorylase, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_729469.2

Status: REVIEWED

UniProtKB/TrEMBL

E8NH18, Q86NQ8, Q9VSW2

Conserved Domains (1) summary

pfam01704
Location:61 → 478

UDPGP; UTP--glucose-1-phosphate uridylyltransferase