Atg4b Autophagy-related 4b [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Atg4bprovided by FlyBase
Official Full Name: Autophagy-related 4bprovided by FlyBase
Primary source: FLYBASE:FBgn0038325
Locus tag: Dmel_CG6194
See related: AllianceGenome:FB:FBgn0038325
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: APG4; atg4; Atg4; ATG4; atg4b; AUT2; CG6194; DmAtg4-like; Dmel\CG6194
Summary: Predicted to enable cysteine-type endopeptidase activity and protein-phosphatidylethanolamide deconjugating activity. Predicted to be involved in macroautophagy and protein processing. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in several structures, including central brain primordium; ganglia; salivary gland; and ventral nerve cord primordium. Orthologous to human ATG4C (autophagy related 4C cysteine peptidase) and ATG4D (autophagy related 4D cysteine peptidase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (15353720..15356924, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (11179442..11182646, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Atg4b Overexpression Extends Lifespan and Healthspan in Drosophila melanogaster.
Title: Atg4b Overexpression Extends Lifespan and Healthspan in Drosophila melanogaster.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type endopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables cysteine-type peptidase activity	IEA Inferred from Electronic Annotation more info
enables protein-phosphatidylethanolamide deconjugating activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-phosphatidylethanolamide deconjugating activity	IEA Inferred from Electronic Annotation more info
enables protein-phosphatidylethanolamide deconjugating activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in aggrephagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in autophagosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in autophagosome assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in autophagy	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in macroautophagy	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitophagy	ISS Inferred from Sequence or Structural Similarity more info
involved_in piecemeal microautophagy of the nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein processing	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info