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    rush rush hour [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31105, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rushprovided by FlyBase
    Official Full Name
    rush hourprovided by FlyBase
    Primary source
    FLYBASE:FBgn0025381
    Locus tag
    Dmel_CG14782
    See related
    AllianceGenome:FB:FBgn0025381
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14782; Dmel\CG14782; EG:80H7.5
    Summary
    Enables phosphatidylinositol binding activity. Involved in endocytosis; endosome organization; and endosome to lysosome transport. Located in early endosome and late endosome. Is expressed in adult fat body; adult head; organism; and spermatozoon. Orthologous to several human genes including PLEKHF2 (pleckstrin homology and FYVE domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See rush in Genome Data Viewer
    Location:
    2B1-2B1; 1-0.2 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (1478552..1481420)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (1372585..1375453)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Rab27 Neighboring gene ncRNA Neighboring gene meiotic 38 Neighboring gene ncRNA Neighboring gene NMDA receptor 2 Neighboring gene stubarista Neighboring gene insomniac

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The phosphoinositide-associated protein Rush hour regulates endosomal trafficking in Drosophila. Gailite I, et al. Mol Biol Cell, 2012 Feb. PMID 22160599, Free PMC Article
    2. Functional genomic screen identifies novel mediators of collagen uptake. Lee TH, et al. Mol Biol Cell, 2014 Mar. PMID 24403604, Free PMC Article
    3. Body size in Drosophila: genetic architecture, allometries and sexual dimorphism. Carreira VP, et al. Heredity (Edinb), 2009 Mar. PMID 19018274
    4. Quantitative genetic analysis of sleep in Drosophila melanogaster. Harbison ST, et al. Genetics, 2008 Apr. PMID 18430954, Free PMC Article
    5. Identification of genes underlying hypoxia tolerance in Drosophila by a P-element screen. Azad P, et al. G3 (Bethesda), 2012 Oct. PMID 23050227, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rush controls trafficking from early to late endosomes and from late endosomes to lysosomes by modulating the activity of Rab proteins.
      Title: The phosphoinositide-associated protein Rush hour regulates endosomal trafficking in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endocytosis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in endosome organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endosome organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endosome to lysosome transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endosome to lysosome transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in early endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in late endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    rush hour
    Names
    CG14782-PA
    CG14782-PB
    rush-PA
    rush-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      1478552..1481420
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_130567.3 → NP_569923.2  rush hour, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_569923.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O76902, Q95RM3
      Related
      FBpp0070249
      Conserved Domains (3) summary
      cd01218
      Location:7 → 129
      PH_Phafin2-like; Phafin2 (also called EAPF, FLJ13187, ZFYVE18 or PLEKHF2) Pleckstrin Homology (PH) domain
      cd15717
      Location:148 → 208
      FYVE_PKHF; FYVE domain found in protein containing both PH and FYVE domains 1 (phafin-1), 2 (phafin-2), and similar proteins
      pfam00169
      Location:39 → 131
      PH; PH domain

    2. NM_001297855.1 → NP_001284784.1  rush hour, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284784.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O76902, Q95RM3
      Conserved Domains (3) summary
      cd01218
      Location:7 → 129
      PH_Phafin2-like; Phafin2 (also called EAPF, FLJ13187, ZFYVE18 or PLEKHF2) Pleckstrin Homology (PH) domain
      cd15717
      Location:148 → 208
      FYVE_PKHF; FYVE domain found in protein containing both PH and FYVE domains 1 (phafin-1), 2 (phafin-2), and similar proteins
      pfam00169
      Location:39 → 131
      PH; PH domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O76902.1 O76902

    Gene LinkOut

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