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    Vha100-1 Vacuolar H[+] ATPase 100kD subunit 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43442, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Vha100-1provided by FlyBase
    Official Full Name
    Vacuolar H[+] ATPase 100kD subunit 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0028671
    Locus tag
    Dmel_CG1709
    See related
    AllianceGenome:FB:FBgn0028671
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:LD21248; CG1709; Dmel\CG1709; V0; V0a; v0a1; v100; V100; V100-1; vha; Vha100; vha100-1
    Summary
    Enables calmodulin binding activity and photoreceptor activity. Involved in several processes, including autophagosome maturation; intracellular pH reduction; and terminal branching, open tracheal system. Located in early endosome and synaptic vesicle. Is expressed in several structures, including adult head; adult heart; adult midgut; embryonic/larval garland cell; and ganglia. Human ortholog(s) of this gene implicated in autosomal recessive osteopetrosis 1; developmental and epileptic encephalopathy 104; and renal tubular acidosis. Orthologous to several human genes including ATP6V0A1 (ATPase H+ transporting V0 subunit a1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Vha100-1 in Genome Data Viewer
    Location:
    98F12-98F12; 3-97 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (29131193..29137980)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (24956915..24963702)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Choline transporter-like 2 Neighboring gene dim gamma-tubulin 6 Neighboring gene Suppressor of ER stress-induced death Neighboring gene Alg13 UDP-N-acetylglucosaminyltransferase subunit Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new view of an old pore. Bajjalieh S. Cell, 2005 May 20. PMID 15907459
    2. On the role of v-ATPase V0a1-dependent degradation in Alzheimer disease. Williamson WR, et al. Commun Integr Biol, 2010 Nov. PMID 21331254, Free PMC Article
    3. miR-1 sustains muscle physiology by controlling V-ATPase complex assembly. Gutiérrez-Pérez P, et al. Sci Adv, 2021 Oct 15. PMID 34652942, Free PMC Article
    4. Conditional depletion of intellectual disability and Parkinsonism candidate gene ATP6AP2 in fly and mouse induces cognitive impairment and neurodegeneration. Dubos A, et al. Hum Mol Genet, 2015 Dec 1. PMID 26376863, Free PMC Article
    5. Lysosomal calcium homeostasis defects, not proton pump defects, cause endo-lysosomal dysfunction in PSEN-deficient cells. Coen K, et al. J Cell Biol, 2012 Jul 9. PMID 22753898, Free PMC Article

    See all (81) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data suggest that Ca(2+)-CaM regulation of V100 may control SNARE complex assembly for a subset of synaptic vesicles that sustain spontaneous release.
      Title: Ca2+-Calmodulin regulates SNARE assembly and spontaneous neurotransmitter release via v-ATPase subunit V0a1.
    2. Neuron-specific, v100-dependent membrane sorting and degradation mechanism is required for brain wiring in Drosophila.
      Title: Guidance receptor degradation is required for neuronal connectivity in the Drosophila nervous system.
    3. V100-1 directs vesicle fusion independently of acidification. V100-1 is required for the acidification of a subset of neuronal lysosomes and autophagosomes but not synaptic vesicles and early endosomes.
      Title: A dual function of V0-ATPase a1 provides an endolysosomal degradation mechanism in Drosophila melanogaster photoreceptors.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables photoreceptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables proton-transporting ATPase activity, rotational mechanism IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to proton-transporting ATPase activity, rotational mechanism ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in autophagosome maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in compound eye development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    NOT involved_in endosomal lumen acidification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular pH reduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in response to light stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in terminal branching, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vacuolar acidification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in early endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of vacuolar proton-transporting V-type ATPase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of vacuolar proton-transporting V-type ATPase, V0 domain IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of vacuolar proton-transporting V-type ATPase, V0 domain ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    vacuolar H[+] ATPase 100kD subunit 1
    Names
    CG1709-PA
    CG1709-PB
    CG1709-PC
    CG1709-PD
    CG1709-PE
    CG1709-PF
    CG1709-PG
    CG1709-PI
    CG1709-PJ
    CG1709-PK
    V0-ATPase a1
    Vha100-1-PA
    Vha100-1-PB
    Vha100-1-PC
    Vha100-1-PD
    Vha100-1-PE
    Vha100-1-PF
    Vha100-1-PG
    Vha100-1-PI
    Vha100-1-PJ
    Vha100-1-PK
    neuron-specific V[[0]] subunit a1
    vacuolar ATPase V0, subunit a1
    vacuolar H[+] ATPase subunit 100-1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      29131193..29137980
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170393.3 → NP_733272.1  vacuolar H[+] ATPase 100kD subunit 1, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733272.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86M57, Q8IML5
      Related
      FBpp0084745
      Conserved Domains (2) summary
      COG1269
      Location:27 → 820
      NtpI; Archaeal/vacuolar-type H+-ATPase subunit I/STV1 [Energy production and conversion]
      pfam01496
      Location:28 → 820
      V_ATPase_I; V-type ATPase 116kDa subunit family

    2. NM_170395.3 → NP_733274.1  vacuolar H[+] ATPase 100kD subunit 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733274.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86M57, Q8IML2, Q8IML3
      Related
      FBpp0084744
      Conserved Domains (2) summary
      COG1269
      Location:27 → 823
      NtpI; Archaeal/vacuolar-type H+-ATPase subunit I/STV1 [Energy production and conversion]
      pfam01496
      Location:28 → 823
      V_ATPase_I; V-type ATPase 116kDa subunit family

    3. NM_170391.3 → NP_733270.1  vacuolar H[+] ATPase 100kD subunit 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733270.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86M57, Q9XZ10
      Related
      FBpp0084743
      Conserved Domains (2) summary
      COG1269
      Location:27 → 842
      NtpI; Archaeal/vacuolar-type H+-ATPase subunit I/STV1 [Energy production and conversion]
      pfam01496
      Location:28 → 842
      V_ATPase_I; V-type ATPase 116kDa subunit family

    4. NM_001170298.2 → NP_001163769.1  vacuolar H[+] ATPase 100kD subunit 1, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163769.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NLA3, Q86M57
      Conserved Domains (2) summary
      COG1269
      Location:27 → 839
      NtpI; Archaeal/vacuolar-type H+-ATPase subunit I/STV1 [Energy production and conversion]
      pfam01496
      Location:28 → 839
      V_ATPase_I; V-type ATPase 116kDa subunit family

    5. NM_170394.3 → NP_733273.1  vacuolar H[+] ATPase 100kD subunit 1, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733273.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86M57, Q8IML4
      Related
      FBpp0084746
      Conserved Domains (2) summary
      COG1269
      Location:27 → 837
      NtpI; Archaeal/vacuolar-type H+-ATPase subunit I/STV1 [Energy production and conversion]
      pfam01496
      Location:28 → 837
      V_ATPase_I; V-type ATPase 116kDa subunit family

    6. NM_170397.3 → NP_733276.3  vacuolar H[+] ATPase 100kD subunit 1, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733276.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86M57, Q8IML2, Q8IML3
      Conserved Domains (2) summary
      COG1269
      Location:27 → 823
      NtpI; Archaeal/vacuolar-type H+-ATPase subunit I/STV1 [Energy production and conversion]
      pfam01496
      Location:28 → 823
      V_ATPase_I; V-type ATPase 116kDa subunit family

    7. NM_143415.3 → NP_651672.1  vacuolar H[+] ATPase 100kD subunit 1, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651672.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86M57, Q9XZ10
      Related
      FBpp0084750
      Conserved Domains (2) summary
      COG1269
      Location:27 → 842
      NtpI; Archaeal/vacuolar-type H+-ATPase subunit I/STV1 [Energy production and conversion]
      pfam01496
      Location:28 → 842
      V_ATPase_I; V-type ATPase 116kDa subunit family

    8. NM_170392.2 → NP_733271.1  vacuolar H[+] ATPase 100kD subunit 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733271.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86M57, Q8IML5
      Related
      FBpp0084748
      Conserved Domains (2) summary
      COG1269
      Location:27 → 820
      NtpI; Archaeal/vacuolar-type H+-ATPase subunit I/STV1 [Energy production and conversion]
      pfam01496
      Location:28 → 820
      V_ATPase_I; V-type ATPase 116kDa subunit family

    9. NM_170396.2 → NP_733275.1  vacuolar H[+] ATPase 100kD subunit 1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733275.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86M57, Q8IML2, Q8IML3
      Related
      FBpp0084749
      Conserved Domains (2) summary
      COG1269
      Location:27 → 823
      NtpI; Archaeal/vacuolar-type H+-ATPase subunit I/STV1 [Energy production and conversion]
      pfam01496
      Location:28 → 823
      V_ATPase_I; V-type ATPase 116kDa subunit family

    10. NM_001170297.1 → NP_001163768.1  vacuolar H[+] ATPase 100kD subunit 1, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163768.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NLA3, Q86M57
      Conserved Domains (2) summary
      COG1269
      Location:27 → 839
      NtpI; Archaeal/vacuolar-type H+-ATPase subunit I/STV1 [Energy production and conversion]
      pfam01496
      Location:28 → 839
      V_ATPase_I; V-type ATPase 116kDa subunit family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NLA3 Q6NLA3
    Q86M57 Q86M57
    Q86P41 Q86P41
    Q8IML3 Q8IML3
    Q8IML4 Q8IML4
    Q8IML5 Q8IML5
    Q9XZ10 Q9XZ10

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