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    shu shutdown [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 45360, updated on 9-Dec-2024

    Summary

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    Official Symbol
    shuprovided by FlyBase
    Official Full Name
    shutdownprovided by FlyBase
    Primary source
    FLYBASE:FBgn0003401
    Locus tag
    Dmel_CG4735
    See related
    AllianceGenome:FB:FBgn0003401
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4735; Dmel\CG4735; Shu
    Summary
    Predicted to enable Hsp90 protein binding activity. Involved in oogenesis; piRNA processing; and retrotransposon silencing. Located in P granule and Yb body. Is expressed in several structures, including egg chamber; germarium; germarium region 1; germline cell; and gonad. Human ortholog(s) of this gene implicated in Williams-Beuren syndrome and spermatogenic failure 77. Orthologous to human FKBP6 (FKBP prolyl isomerase family member 6 (inactive)). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See shu in Genome Data Viewer
    Location:
    60A3-60A3; 2-105 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23841461..23843286, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19728984..19730809, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene long non-coding RNA:CR44805 Neighboring gene uncharacterized protein Neighboring gene Synaptosomal-associated protein 29kDa Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Analyses of the Drosophila quit, ovarian tumor and shut down mutants in oocyte differentiation using in situ hybridisation. Tirronen M, et al. Mech Dev, 1993 Jan. PMID 8443104
    2. Functional editing of endogenous genes through rapid selection of cell pools (Rapid generation of endogenously tagged genes in Drosophila ovarian somatic sheath cells). Meng Q, et al. Nucleic Acids Res, 2022 Aug 26. PMID 35639929, Free PMC Article
    3. Recruitment of Armitage and Yb to a transcript triggers its phased processing into primary piRNAs in Drosophila ovaries. Pandey RR, et al. PLoS Genet, 2017 Aug. PMID 28827804, Free PMC Article
    4. Acetyltransferase Enok regulates transposon silencing and piRNA cluster transcription. Tsai SY, et al. PLoS Genet, 2021 Feb. PMID 33524038, Free PMC Article
    5. In between: gypsy in Drosophila melanogaster reveals new insights into endogenous retrovirus evolution. Touret F, et al. Viruses, 2014 Dec 9. PMID 25502325, Free PMC Article

    See all (68) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables Hsp90 protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in oogenesis HMP PubMed 
    involved_in oogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in piRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in primary piRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in secondary piRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transposable element silencing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in P granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Yb body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    shutdown
    Names
    CG4735-PA
    Shut-down
    shu-PA
    shut down
    NP_611837.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      23841461..23843286 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137993.4 → NP_611837.1  shutdown [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611837.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W1I9
      Related
      FBpp0072146
      Conserved Domains (2) summary
      sd00006
      Location:218 → 257
      TPR; TPR repeat [structural motif]
      pfam00254
      Location:96 → 189
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W1I9.1 Q9W1I9

    Gene LinkOut

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