U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    noc no ocelli [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34847, updated on 27-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    nocprovided by FlyBase
    Official Full Name
    no ocelliprovided by FlyBase
    Primary source
    FLYBASE:FBgn0005771
    Locus tag
    Dmel_CG4491
    See related
    AllianceGenome:FB:FBgn0005771
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BG:DS04641.1; br22; CG4491; Dmel\CG4491; el; l(2)35Ba; l(2)35Ba/nocA; l(2)br22; l35Ba; Noc; nocA; NocA; noc[A]
    Summary
    Involved in several processes, including nervous system development; ocellus development; and terminal branching, open tracheal system. Predicted to be active in nucleus. Is expressed in several structures, including anlage in statu nascendi; embryonic/larval midgut primordium; head epidermis primordium; procephalic segment; and tracheal primordium. Orthologous to human ZNF503 (zinc finger protein 503) and ZNF703 (zinc finger protein 703). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See noc in Genome Data Viewer
    Location:
    35B2-35B2; 2-50 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (14490859..14494019)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (14490859..14494019)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44730 Neighboring gene long non-coding RNA:CR44731 Neighboring gene transfer RNA:Proline-AGG 1-1 Neighboring gene long non-coding RNA:CR45303

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Spontaneous excision of a large composite transposable element of Drosophila melanogaster. Chia W, et al. Nature, 1985 Jul 4-10. PMID 2989710
    2. Characterization of the FB-NOF transposable element of Drosophila melanogaster. Harden N, et al. Genetics, 1990 Oct. PMID 2174013, Free PMC Article
    3. The molecular structure of TE146 and its derivatives in Drosophila melanogaster. Lovering R, et al. Genetics, 1991 Jun. PMID 1649070, Free PMC Article
    4. The molecular analyses of an antimorphic mutation of Drosophila melanogaster, Scutoid. McGill S, et al. Genetics, 1988 Jul. PMID 16052738, Free PMC Article
    5. Evolution of the NET (NocA, Nlz, Elbow, TLP-1) protein family in metazoans: insights from expression data and phylogenetic analysis. Pereira F, et al. Sci Rep, 2016 Dec 8. PMID 27929068, Free PMC Article

    See all (112) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. we show that Elb/Noc specifically interact with the transcription factor Orthodenticle (Otd)/Otx, a crucial regulator of rhodopsin gene transcription.
      Title: Genetic dissection of photoreceptor subtype specification by the Drosophila melanogaster zinc finger proteins elbow and no ocelli.
    2. A disruption in R7 and R8 cell patterning in Scutoid mutants is due to inappropriate signals from Rh4-expressing R7 cells inducing Rh5 expression in adjacent R8 cells.
      Title: Disruption of photoreceptor cell patterning in the Drosophila Scutoid mutant.
    3. regulation of the size of the eye-head primordium by elbow and no ocelli is crucial for proper fate specification and generation of the adult structures
      Title: Growth control in the proliferative region of the Drosophila eye-head primordium: the elbow-noc gene complex.
    4. Results identify two proteins, elbow and noc, which form a complex and participate in the determination of specific tracheal branch fates.
      Title: Elbow and Noc define a family of zinc finger proteins controlling morphogenesis of specific tracheal branches.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in brain development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in compound eye photoreceptor fate commitment IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in eye-antennal disc development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in leg disc development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ocellus development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in open tracheal system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in terminal branching, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in wing disc development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    no ocelli
    Names
    CG4491-PA
    CG4491-PB
    no-ocelli
    noc-PA
    noc-PB

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      14490859..14494019
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057569.3 → NP_476917.1  no ocelli, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476917.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24423
      UniProtKB/TrEMBL
      X2J9V3
      Related
      FBpp0080215
      Conserved Domains (2) summary
      sd00017
      Location:404 → 430
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:402 → 430
      zf-C2H2; Zinc finger, C2H2 type

    2. NM_001299003.1 → NP_001285932.1  no ocelli, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285932.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24423
      UniProtKB/TrEMBL
      X2J9V3
      Conserved Domains (2) summary
      sd00017
      Location:404 → 430
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:402 → 430
      zf-C2H2; Zinc finger, C2H2 type
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q24423.1 Q24423
    X2J9V3 X2J9V3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous