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    PolI DNA polymerase iota [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40965, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PolIprovided by FlyBase
    Official Full Name
    DNA polymerase iotaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037554
    Locus tag
    Dmel_CG7602
    See related
    AllianceGenome:FB:FBgn0037554
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AAF54198; CG7602; Dm-Poliota; Dmel\CG7602; DNA Pol II-iota; DNA-pol iota; DNApol-i; DNApol-iota; drad30B; Poliota
    Summary
    Enables DNA-directed DNA polymerase activity. Involved in translesion synthesis. Is expressed in organism. Orthologous to human POLI (DNA polymerase iota). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See PolI in Genome Data Viewer
    Location:
    84F4-84F5; 3-48 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (8233507..8237389)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (4059229..4063111)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45551 Neighboring gene long non-coding RNA:CR45550 Neighboring gene antisense RNA:CR45549 Neighboring gene transcriptional Adaptor 2b Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutagenic and nonmutagenic bypass of DNA lesions by Drosophila DNA polymerases dpoleta and dpoliota. Ishikawa T, et al. J Biol Chem, 2001 May 4. PMID 11297519
    2. Comparative analysis of in vivo interactions between Rev1 protein and other Y-family DNA polymerases in animals and yeasts. Kosarek JN, et al. DNA Repair (Amst), 2008 Mar 1. PMID 18242152, Free PMC Article
    3. Drosophila Ada2b is required for viability and normal histone H3 acetylation. Qi D, et al. Mol Cell Biol, 2004 Sep. PMID 15340070, Free PMC Article
    4. Realized immune response is enhanced in long-lived puc and chico mutants but is unaffected by dietary restriction. Libert S, et al. Mol Immunol, 2008 Feb. PMID 17681604
    5. TRIP/NOPO E3 ubiquitin ligase promotes ubiquitylation of DNA polymerase η. Wallace HA, et al. Development, 2014 Mar. PMID 24553286, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-directed DNA polymerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-directed DNA polymerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-directed DNA polymerase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables damaged DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translesion synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translesion synthesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in translesion synthesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA polymerase iota
    Names
    CG7602-PA
    CG7602-PB
    CG7602-PC
    DNApol-iota
    PolI-PA
    PolI-PB
    PolI-PC
    NP_001287227.1
    NP_649772.1
    NP_731214.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      8233507..8237389
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169207.2 → NP_731214.1  DNA polymerase iota, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731214.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VHV1
      Related
      FBpp0081293
      Conserved Domains (1) summary
      cd01703
      Location:18 → 411
      PolY_Pol_iota; DNA Polymerase iota

    2. NM_141515.3 → NP_649772.1  DNA polymerase iota, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649772.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VHV1
      Related
      FBpp0081294
      Conserved Domains (1) summary
      cd01703
      Location:18 → 411
      PolY_Pol_iota; DNA Polymerase iota

    3. NM_001300298.1 → NP_001287227.1  DNA polymerase iota, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287227.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VHV1
      Conserved Domains (1) summary
      cd01703
      Location:18 → 411
      PolY_Pol_iota; DNA Polymerase iota
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VHV1.1 Q9VHV1

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