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    D1 D1 chromosomal protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41095, updated on 9-Dec-2024

    Summary

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    Official Symbol
    D1provided by FlyBase
    Official Full Name
    D1 chromosomal proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000412
    Locus tag
    Dmel_CG9745
    See related
    AllianceGenome:FB:FBgn0000412
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9745; dD1; dHMGx; Dmel\CG9745; EP(3)0473; HMGI; RE69409
    Summary
    Enables minor groove of adenine-thymine-rich DNA binding activity and satellite DNA binding activity. Located in chromosome; cytoplasm; and nucleus. Part of nucleosome. Is expressed in embryonic brain; larval central nervous system; larval ventral nerve cord; and organism. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    Location:
    85D1-85D1; 3-48 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9238083..9240654, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5063805..5066376, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene pumilio Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45196 Neighboring gene Vacuolar protein sorting 15 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation and sequencing of cDNA clones encoding Drosophila chromosomal protein D1. A repeating motif in proteins which recognize at DNA. Ashley CT, et al. J Biol Chem, 1989 May 15. PMID 2542275
    2. Drosophila D1 overexpression induces ectopic pairing of polytene chromosomes and is deleterious to development. Smith MB, et al. Chromosoma, 2010 Jun. PMID 20127347
    3. The AT-hook protein D1 is essential for Drosophila melanogaster development and is implicated in position-effect variegation. Aulner N, et al. Mol Cell Biol, 2002 Feb. PMID 11809812, Free PMC Article
    4. Insect proteins homologous to mammalian high mobility group proteins I/Y (HMG I/Y). Characterization and binding to linear and four-way junction DNA. Claus P, et al. J Biol Chem, 1994 Dec 30. PMID 7806532
    5. Protein D1 preferentially binds A + T-rich DNA in vitro and is a component of Drosophila melanogaster nucleosomes containing A + T-rich satellite DNA. Levinger L, et al. Proc Natl Acad Sci U S A, 1982 Dec. PMID 6818540, Free PMC Article

    See all (95) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. D1 overexpression induces ectopic pairing of polytene chromosomes and is deleterious to development.
      Title: Drosophila D1 overexpression induces ectopic pairing of polytene chromosomes and is deleterious to development.
    2. Results suggest that displacement of the heterochromatin proteins D1, HP1 and topoisomerase II from satellite III result in stochastic chromatin opening and desilencing of the nearby white gene in white-mottled flies.
      Title: Displacement of D1, HP1 and topoisomerase II from satellite heterochromatin by a specific polyamide.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables minor groove of adenine-thymine-rich DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables satellite DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nucleosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in polytene chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    D1 chromosomal protein
    Names
    CG9745-PA
    CG9745-PC
    CG9745-PD
    D1-PA
    D1-PC
    D1-PD
    chromosomal protein D1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      9238083..9240654 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169262.2 → NP_731320.1  D1 chromosomal protein, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731320.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P22058, Q24215, Q8SX69, Q9VHH3
      UniProtKB/TrEMBL
      A4V2K7
      Related
      FBpp0081467

    2. NM_169261.3 → NP_731319.1  D1 chromosomal protein, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731319.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P22058, Q24215, Q8SX69, Q9VHH3
      UniProtKB/TrEMBL
      A4V2K7
      Related
      FBpp0290739

    3. NM_079562.3 → NP_524286.1  D1 chromosomal protein, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524286.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P22058, Q24215, Q8SX69, Q9VHH3
      UniProtKB/TrEMBL
      A4V2K7
      Related
      FBpp0081468
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A4V2K7 A4V2K7
    P22058.3 P22058

    Gene LinkOut

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