Atg18a Autophagy-related 18a [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Atg18aprovided by FlyBase
Official Full Name: Autophagy-related 18aprovided by FlyBase
Primary source: FLYBASE:FBgn0035850
Locus tag: Dmel_CG7986
See related: AllianceGenome:FB:FBgn0035850
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: atg18; Atg18; ATG18; atg18.1; ATG18.1; atg18a; Atg18A; ATG18a; CG7986; Dmel\CG7986
Summary: Predicted to enable phosphatidylinositol-3,5-bisphosphate binding activity and phosphatidylinositol-3-phosphate binding activity. Involved in several processes, including T-tubule organization; larval midgut cell programmed cell death; and macroautophagy. Located in autophagosome. Is expressed in several structures, including adult head; anlage in statu nascendi; antennal anlage; central brain anlage; and mesoderm. Orthologous to several human genes including WIPI2 (WD repeat domain, phosphoinositide interacting 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 66B11-66B11; 3-22 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (8186857..8191118)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (8179957..8184218)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Autophagy impairment and lifespan reduction caused by Atg1 RNAi or Atg18 RNAi expression in adult fruit flies (Drosophila melanogaster).
Title: Autophagy impairment and lifespan reduction caused by Atg1 RNAi or Atg18 RNAi expression in adult fruit flies (Drosophila melanogaster).
These findings provide the first direct evidence of the importance of Atg2-Atg18/Atg9 autophagy complex in the maintenance of mitochondrial integrity and, regulation of heart and muscle functions in Drosophila.
Title: Atg2, Atg9 and Atg18 in mitochondrial integrity, cardiac function and healthspan in Drosophila.
The simultaneous interaction of Atg18 with both Atg9 and Ref(2)P raises the possibility that Atg18 may facilitate selective degradation of ubiquitinated protein aggregates by autophagy.
Title: Different effects of Atg2 and Atg18 mutations on Atg8a and Atg9 trafficking during starvation in Drosophila.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables phosphatidylinositol-3,5-bisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-3-phosphate binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in T-tubule organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in autophagosome assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in autophagy of mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
involved_in autophagy of peroxisome	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glycophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval midgut cell programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval midgut histolysis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in macroautophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein lipidation involved in autophagosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to phagophore assembly site	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of defense response to virus	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in autophagosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in phagophore assembly site membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Autophagy-related 18a

Names: Atg18a-PA; Atg18a-PB; Atg18a-PC; Atg18a-PD; Atg18a-PE; Atg18a-PF; Atg18a-PG; Autophagy-specific gene 18; Autophagy-specific gene 18a; CG7986-PA; CG7986-PB; CG7986-PC; CG7986-PD; CG7986-PE; CG7986-PF; CG7986-PG

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

8186857..8191118

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001300048.1 → NP_001286977.1 Autophagy-related 18a, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001286977.1

Status: REVIEWED

UniProtKB/TrEMBL

Q960R7, Q9VSF0

Conserved Domains (3) summary

COG2319
Location:15 → 278

WD40; WD40 repeat [General function prediction only]

sd00039
Location:143 → 180

7WD40; WD40 repeat [structural motif]

cl02567
Location:23 → 269

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_206301.4 → NP_996023.1 Autophagy-related 18a, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996023.1

Status: REVIEWED

UniProtKB/TrEMBL

Q960R7, Q9VSF0

Conserved Domains (3) summary

COG2319
Location:15 → 278

WD40; WD40 repeat [General function prediction only]

sd00039
Location:143 → 180

7WD40; WD40 repeat [structural motif]

cl02567
Location:23 → 269

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001274636.1 → NP_001261565.1 Autophagy-related 18a, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261565.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PER1

Conserved Domains (3) summary

COG2319
Location:15 → 278

WD40; WD40 repeat [General function prediction only]

sd00039
Location:143 → 180

7WD40; WD40 repeat [structural motif]

cl02567
Location:23 → 269

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_168259.3 → NP_729341.1 Autophagy-related 18a, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_729341.1

Status: REVIEWED

UniProtKB/TrEMBL

Q960R7, Q9VSF0

Related

FBpp0076415

Conserved Domains (3) summary

COG2319
Location:15 → 278

WD40; WD40 repeat [General function prediction only]

sd00039
Location:143 → 180

7WD40; WD40 repeat [structural motif]

cl02567
Location:23 → 269

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001274637.1 → NP_001261566.1 Autophagy-related 18a, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261566.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PHS3

Conserved Domains (3) summary

COG2319
Location:158 → 345

WD40; WD40 repeat [General function prediction only]

sd00039
Location:143 → 180

7WD40; WD40 repeat [structural motif]

cl02567
Location:23 → 269

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_139927.4 → NP_648184.1 Autophagy-related 18a, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_648184.1

Status: REVIEWED

UniProtKB/TrEMBL

Q960R7, Q9VSF0

Related

FBpp0076414

Conserved Domains (3) summary

COG2319
Location:15 → 278

WD40; WD40 repeat [General function prediction only]

sd00039
Location:143 → 180

7WD40; WD40 repeat [structural motif]

cl02567
Location:23 → 269

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001274635.1 → NP_001261564.1 Autophagy-related 18a, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261564.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PEY7

Conserved Domains (3) summary

COG2319
Location:158 → 345

WD40; WD40 repeat [General function prediction only]

sd00039
Location:143 → 180

7WD40; WD40 repeat [structural motif]

cl02567
Location:23 → 269

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...