Cdk1 Cyclin-dependent kinase 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Cdk1provided by FlyBase
Official Full Name: Cyclin-dependent kinase 1provided by FlyBase
Primary source: FLYBASE:FBgn0004106
Locus tag: Dmel_CG5363
See related: AllianceGenome:FB:FBgn0004106
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 5363; cdc; cdc2; Cdc2; CDC2; cdc2Dm; CDCDm; Cdk-1; cdk1; CDK1; CDK1/CDC2; CG5363; Dcdc2; dCdk1; Dm cdc2; Dmcdc2; DmCdc2; DmCdk1; Dmel\CG5363; group 4; l(2)31Eh
Summary: Enables cyclin-dependent protein serine/threonine kinase activity. Involved in several processes, including mitotic G2 DNA damage checkpoint signaling; mitotic cell cycle phase transition; and oogenesis. Located in fusome. Is expressed in several structures, including embryonic/larval midgut primordium; ganglia; head epidermis primordium; imaginal disc; and mesoderm. Human ortholog(s) of this gene implicated in breast cancer; cervical cancer; and urinary bladder cancer. Orthologous to human CDK1 (cyclin dependent kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 31D11-31D11; 2-41 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (10384739..10386262, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (10384739..10386262, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A CDK1 phosphorylation site on Drosophila PAR-3 regulates neuroblast polarisation and sensory organ formation.
Title: A CDK1 phosphorylation site on Drosophila PAR-3 regulates neuroblast polarisation and sensory organ formation.
Lethal Giant Disc is a target of Cdk1 and regulates ESCRT-III localization during germline stem cell abscission.
Title: Lethal Giant Disc is a target of Cdk1 and regulates ESCRT-III localization during germline stem cell abscission.
Cyclin E and Cdk1 regulate the termination of germline transit-amplification process in Drosophila testis.
Title: Cyclin E and Cdk1 regulate the termination of germline transit-amplification process in Drosophila testis.
Temperature-Induced uncoupling of cell cycle regulators.
Title: Temperature-Induced uncoupling of cell cycle regulators.
Cyclin B3 activates the Anaphase-Promoting Complex/Cyclosome in meiosis and mitosis.
Title: Cyclin B3 activates the Anaphase-Promoting Complex/Cyclosome in meiosis and mitosis.
Cyclin B1-Cdk1 localized at the spindle midzone in an Aurora B-dependent manner, with incompletely separated chromosomes showing the highest Cdk1 activity. Slowing down anaphase chromosome motion delayed Cyclin B1 degradation and mitotic exit in an Aurora B-dependent manner.
Title: Spatiotemporal control of mitotic exit during anaphase by an aurora B-Cdk1 crosstalk.
Physical interaction between p115 and Cdk1, suggests that p115 sequesters or re-localizes Cdk1 during mitosis to allow the complete activation of Cdk1 and consequently correct progression through mitosis in Drosophila imaginal cells.
Title: Drosophila p115 is required for Cdk1 activation and G2/M cell cycle transition.
Here the authors show that CDK1 phosphorylation of GNU negatively regulates PNG kinase activity.
Title: Control of PNG kinase, a key regulator of mRNA translation, is coupled to meiosis completion at egg activation.
Cdk1 waves are not controlled by the mitotic switch but by a double-negative feedback between Cdk1 and Chk1. In Drosophila embryos, Cdk1 positive feedback serves primarily to ensure the rapid onset of mitosis, while wave propagation is regulated by S phase events.
Title: Waves of Cdk1 Activity in S Phase Synchronize the Cell Cycle in Drosophila Embryos.
Cdk1 phosphorylates the conserved centriole protein Sas-4 during mitosis. This creates a Polo-docking site that helps recruit Polo to daughter centrioles.
Title: Cdk1 Phosphorylates Drosophila Sas-4 to Recruit Polo to Daughter Centrioles and Convert Them to Centrosomes.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables cyclin-dependent protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cyclin-dependent protein serine/threonine kinase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables cyclin-dependent protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in G1/S transition of mitotic cell cycle	IGI Inferred from Genetic Interaction more info	PubMed
involved_in G2/M transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in G2/M transition of mitotic cell cycle	IGI Inferred from Genetic Interaction more info	PubMed
involved_in G2/M transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in asymmetric neuroblast division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic development via the syncytial blastoderm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in follicle cell of egg chamber development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germarium-derived cystoblast division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male meiotic nuclear division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic G2 DNA damage checkpoint signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic G2 DNA damage checkpoint signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic G2/M transition checkpoint	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated DNA replication initiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mitotic cell cycle phase transition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatogonial cell division	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in fusome	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Cyclin-dependent kinase 1

Names: CG5363-PA; Cdk1-PA; cdc2; cdc2 kinase; cell division control; cyclin dependent kinase; cyclin-dependent kinase; protein 2

NP_476797.1

EC 2.7.11.1

EC 2.7.11.22

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

10384739..10386262 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_057449.4 → NP_476797.1 Cyclin-dependent kinase 1 [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476797.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A0ANT1, P23572, Q86FT5, Q86FT6, Q86FT7, Q86FT8, Q86FT9, Q9TX68, Q9TX69, Q9TX70, Q9TX71, Q9TX72, Q9TX73, Q9TX74, Q9VKX5

UniProtKB/TrEMBL

C0MJ66

Related

FBpp0079641

Conserved Domains (1) summary

cd07861
Location:3 → 287

STKc_CDK1_euk; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 1 from higher eukaryotes