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    Gga Golgi-localized, gamma-adaptin ear containing, ARF binding protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31902, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ggaprovided by FlyBase
    Official Full Name
    Golgi-localized, gamma-adaptin ear containing, ARF binding proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030141
    Locus tag
    Dmel_CG3002
    See related
    AllianceGenome:FB:FBgn0030141
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3002; dGGA; Dmel\CG3002; dmGGA; DmGGA1; GGA
    Summary
    Enables clathrin adaptor activity and clathrin heavy chain binding activity. Involved in post-Golgi vesicle-mediated transport. Located in several cellular components, including clathrin-coated vesicle; perinuclear region of cytoplasm; and trans-Golgi network. Is expressed in several structures, including adult brain cell body rind; adult mushroom body beta-lobe; anterior-posterior subdivision of organism; male germline cell; and retina. Used to study lysosomal storage disease and neurodegenerative disease. Orthologous to several human genes including GGA1 (golgi associated, gamma adaptin ear containing, ARF binding protein 1) and GGA2 (golgi associated, gamma adaptin ear containing, ARF binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Gga in Genome Data Viewer
    Location:
    8F1-8F1; 1-29 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (9601030..9604280)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (9495063..9498313)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45542 Neighboring gene long non-coding RNA:CR45543 Neighboring gene Lst8 Neighboring gene Lysyl-tRNA synthetase Neighboring gene Hecw ubiquitin protein ligase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The novel Drosophila lysosomal enzyme receptor protein mediates lysosomal sorting in mammalian cells and binds mammalian and Drosophila GGA adaptors. Dennes A, et al. J Biol Chem, 2005 Apr 1. PMID 15664992
    2. The unique GGA clathrin adaptor of Drosophila melanogaster is not essential. Luan S, et al. PLoS One, 2012. PMID 23028818, Free PMC Article
    3. A potential role for the clathrin adaptor GGA in Drosophila spermatogenesis. Hirst J, et al. BMC Cell Biol, 2011 May 20. PMID 21599933, Free PMC Article
    4. Drosophila GGA model: an ultimate gateway to GGA analysis. Eissenberg JC, et al. Traffic, 2011 Dec. PMID 21923734, Free PMC Article
    5. Functional characterization of protein-sorting machineries at the trans-Golgi network in Drosophila melanogaster. Kametaka S, et al. J Cell Sci, 2010 Feb 1. PMID 20067992, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Homozygous and hemizygous flies for the mutatited GGA allele are viable and fertile.
      Title: The unique GGA clathrin adaptor of Drosophila melanogaster is not essential.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables clathrin adaptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables clathrin heavy chain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi to plasma membrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in post-Golgi vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in clathrin-coated vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in trans-Golgi network IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Golgi-localized, gamma-adaptin ear containing, ARF binding protein
    Names
    CG3002-PB
    Gga-PB
    Golgi-localised, gamma-ear containing, ADP ribosylation factor-binding

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      9601030..9604280
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132343.4 → NP_572571.1  Golgi-localized, gamma-adaptin ear containing, ARF binding protein [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572571.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95TM1, Q9W329
      Related
      FBpp0071298
      Conserved Domains (3) summary
      smart00809
      Location:543 → 644
      Alpha_adaptinC2; Adaptin C-terminal domain
      cd03567
      Location:7 → 144
      VHS_GGA; VHS domain family, GGA subfamily; GGA (Golgi-localized, Gamma-ear-containing, Arf-binding) comprise a subfamily of ubiquitously expressed, monomeric, motif-binding cargo/clathrin adaptor proteins. The VHS domain has a superhelical structure similar to ...
      pfam03127
      Location:210 → 284
      GAT; GAT domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95RK8 Q95RK8
    Q9W329 Q9W329

    Gene LinkOut

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