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    TM9SF2 Transmembrane 9 superfamily protein member 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35335, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TM9SF2provided by FlyBase
    Official Full Name
    Transmembrane 9 superfamily protein member 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0032880
    Locus tag
    Dmel_CG9318
    See related
    AllianceGenome:FB:FBgn0032880
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    38E.10; CG9318; Dmel\CG9318
    Summary
    Involved in negative regulation of peptidoglycan recognition protein signaling pathway. Located in cytoplasmic vesicle and plasma membrane. Is expressed in several structures, including embryonic/larval midgut primordium; epithelium; gland; gut section; and mesoderm. Orthologous to human TM9SF2 (transmembrane 9 superfamily member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See TM9SF2 in Genome Data Viewer
    Location:
    38E4-38E5; 2-54 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (20730416..20734309, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (20730416..20734309, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Carcinine transporter Neighboring gene Female sterile (2) Ketel Neighboring gene Alpha-methylacyl-CoA racemase Neighboring gene Nucleostemin 4 Neighboring gene RHAU helicase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The DRE motif is a key component in the expression regulation of the importin-beta encoding Ketel gene in Drosophila. Villanyi Z, et al. Mech Dev, 2008 Sep-Oct. PMID 18656533
    2. The nonaspanins TM9SF2 and TM9SF4 regulate the plasma membrane localization and signalling activity of the peptidoglycan recognition protein PGRP-LC in Drosophila. Perrin J, et al. J Innate Immun, 2015. PMID 25139117, Free PMC Article
    3. Comparative analysis of nonaspanin protein sequences and expression studies in zebrafish. Pruvot B, et al. Immunogenetics, 2010 Oct. PMID 20820770
    4. TM9SF4 is required for Drosophila cellular immunity via cell adhesion and phagocytosis. Bergeret E, et al. J Cell Sci, 2008 Oct 15. PMID 18796536
    5. Map position and expression of the genes in the 38 region of Drosophila. Butler H, et al. Genetics, 2001 Aug. PMID 11514449, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Silencing TM9SF4 prevents plasma membrane localization of PGRP-LC, whereas silencing TM9SF2 does not, which may account for the non-redundant role of TM9SF4 in phagocytosis of Gram-negative bacteria.
      Title: The nonaspanins TM9SF2 and TM9SF4 regulate the plasma membrane localization and signalling activity of the peptidoglycan recognition protein PGRP-LC in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in negative regulation of peptidoglycan recognition protein signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transmembrane 9 superfamily protein member 2
    Names
    CG9318-PA
    CG9318-PB
    TM9SF2-PA
    TM9SF2-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      20730416..20734309 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273708.1 → NP_001260637.1  transmembrane 9 superfamily protein member 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260637.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VIK1
      Conserved Domains (1) summary
      pfam02990
      Location:64 → 613
      EMP70; Endomembrane protein 70

    2. NM_136209.3 → NP_610053.1  transmembrane 9 superfamily protein member 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610053.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VIK1
      Related
      FBpp0080923
      Conserved Domains (1) summary
      pfam02990
      Location:64 → 613
      EMP70; Endomembrane protein 70
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VIK1 Q9VIK1

    Gene LinkOut

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