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    KRT20 keratin 20 [ Homo sapiens (human) ]

    Gene ID: 54474, updated on 10-Dec-2024

    Summary

    Official Symbol
    KRT20provided by HGNC
    Official Full Name
    keratin 20provided by HGNC
    Primary source
    HGNC:HGNC:20412
    See related
    Ensembl:ENSG00000171431 MIM:608218; AllianceGenome:HGNC:20412
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    K20; CD20; CK20; CK-20; KRT21
    Summary
    The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This cytokeratin is a major cellular protein of mature enterocytes and goblet cells and is specifically expressed in the gastric and intestinal mucosa. The type I cytokeratin genes are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in small intestine (RPKM 435.8), colon (RPKM 405.3) and 3 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See KRT20 in Genome Data Viewer
    Location:
    17q21.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (40875889..40885242, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (41740198..41749557, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (39032141..39041494, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr17:38975907-38977106 Neighboring gene KRT10 antisense RNA 1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:38983418-38984617 Neighboring gene keratin 10 Neighboring gene uncharacterized LOC105371777 Neighboring gene Sharpr-MPRA regulatory region 3631 Neighboring gene keratin 12 Neighboring gene uncharacterized LOC107985072 Neighboring gene keratin 23 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:39109689-39110888 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr17:39112787-39113986 Neighboring gene keratin 39

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (21 hits/1256 screens)

    EBI GWAS Catalog

    Description
    Identification of 15 loci influencing height in a Korean population.
    EBI GWAS Catalog

    Interactions

    General gene information

    Clone Names

    • MGC35423

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in apoptotic process  
    involved_in cellular response to starvation  
    involved_in epithelial cell differentiation  
    involved_in intermediate filament organization  
    involved_in intermediate filament organization PubMed 
    involved_in regulation of protein secretion  
    Component Evidence Code Pubs
    located_in cytoplasm PubMed 
    is_active_in cytoskeleton  
    located_in cytosol  
    located_in cytosol  
    located_in intermediate filament PubMed 
    located_in intermediate filament cytoskeleton  

    General protein information

    Preferred Names
    keratin, type I cytoskeletal 20
    Names
    cytokeratin 20
    keratin 20, type I
    protein IT

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012286.1 RefSeqGene

      Range
      4986..14339
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_019010.3 → NP_061883.1  keratin, type I cytoskeletal 20 precursor

      See identical proteins and their annotated locations for NP_061883.1

      Status: REVIEWED

      Source sequence(s)
      BC031559, DA426874, DB242980
      Consensus CDS
      CCDS11379.1
      UniProtKB/Swiss-Prot
      B2R6W7, P35900
      Related
      ENSP00000167588.3, ENST00000167588.4
      Conserved Domains (1) summary
      pfam00038
      Location:69 → 380
      Filament; Intermediate filament protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      40875889..40885242 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NW_003871091.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      25157..34510 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      41740198..41749557 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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