Sds serine dehydratase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sdsprovided by MGI
Official Full Name: serine dehydrataseprovided by MGI
Primary source: MGI:MGI:98270
See related: Ensembl:ENSMUSG00000029597 AllianceGenome:MGI:98270
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SDH; 4432411H13Rik
Summary: Predicted to enable ammonia-lyase activity; protein homodimerization activity; and pyridoxal phosphate binding activity. Predicted to be involved in carboxylic acid metabolic process and protein-containing complex assembly. Predicted to be located in cytosol and mitochondrion. Is expressed in several structures, including genitourinary system; immune system; liver; musculature; and stomach. Orthologous to human SDS (serine dehydratase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward liver adult (RPKM 181.2) See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 5 F; 5 60.63 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (120614612..120621997)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (120476547..120483932)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This persistent conditioned hyperactivity in The SR-/- subjects supports the conclusion that intact NMDA receptor signaling is critical to extinction learning.
Title: Altered acquisition and extinction of amphetamine-paired context conditioning in genetic mouse models of altered NMDA receptor function.

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3)

General gene information

Go to the top of the page Help

Markers

Sds (e-PCR), detects polymorphism
- UniSTS:471097

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables L-serine ammonia-lyase activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-serine ammonia-lyase activity	IEA Inferred from Electronic Annotation more info
enables L-serine ammonia-lyase activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info
enables pyridoxal phosphate binding	ISO Inferred from Sequence Orthology more info
enables threonine deaminase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-serine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-serine catabolic process	IEA Inferred from Electronic Annotation more info
involved_in L-serine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in gluconeogenesis	IEA Inferred from Electronic Annotation more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in pyruvate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in pyruvate biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: L-serine dehydratase/L-threonine deaminase

Names: L-serine deaminase; L-threonine dehydratase; TDH

NP_663540.1

EC 4.3.1.17

EC 4.3.1.19

XP_006530361.1

EC 4.3.1.17

EC 4.3.1.19

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145565.1 → NP_663540.1 L-serine dehydratase/L-threonine deaminase

See identical proteins and their annotated locations for NP_663540.1

Status: PROVISIONAL

Source sequence(s)

BC021950

Consensus CDS

CCDS19619.1

UniProtKB/Swiss-Prot

Q8VBT2

UniProtKB/TrEMBL

Q3UEN6

Related

ENSMUSP00000064849.8, ENSMUST00000066540.14

Conserved Domains (2) summary

cd06448
Location:10 → 320

L-Ser-dehyd; Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- , D-serine, or L-threonine to pyruvate/ketobutyrate and ammonia.

pfam00291
Location:10 → 304

PALP; Pyridoxal-phosphate dependent enzyme

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

120614612..120621997

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006530298.4 → XP_006530361.1 L-serine dehydratase/L-threonine deaminase isoform X1

Conserved Domains (1) summary

cd06448
Location:35 → 345

L-Ser-dehyd; Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- , D-serine, or L-threonine to pyruvate/ketobutyrate and ammonia.