Cyp2j5 cytochrome P450, family 2, subfamily j, polypeptide 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cyp2j5provided by MGI
Official Full Name: cytochrome P450, family 2, subfamily j, polypeptide 5provided by MGI
Primary source: MGI:MGI:1270149
See related: Ensembl:ENSMUSG00000052520 AllianceGenome:MGI:1270149
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable heme binding activity; isomerase activity; and monooxygenase activity. Acts upstream of or within angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure; positive regulation of estrogen secretion; and renal tubular secretion. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Is expressed in liver and metanephros. Human ortholog(s) of this gene implicated in hypertension; myocardial infarction; pulmonary hypertension; renal fibrosis; and renal hypertension. Orthologous to human CYP2J2 (cytochrome P450 family 2 subfamily J member 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in kidney adult (RPKM 77.6), liver adult (RPKM 37.6) and 1 other tissue See more
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Genomic context

Location:: 4 C5; 4 44.71 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (96517010..96552391, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (96627432..96664171, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Microsomal epoxide hydrolase forms complex with CYP2J5 in the endoplasmic reticulum.
Title: Evidence for a complex formation between CYP2J5 and mEH in living cells by FRET analysis of membrane protein interaction in the endoplasmic reticulum (FAMPIR).
Data indicate that cardiac-specific overexpression of arachidonate epoxygenase (CYP2J5) significantly protects against diabetic cardiomyopathy, which may be due to improved cardiac insulin resistance, glucose uptake, and reversal of cardiac hypertrophy.
Title: Cardiac-specific overexpression of CYP2J2 attenuates diabetic cardiomyopathy in male streptozotocin-induced diabetic mice.
Cytochrome P450 2J2 is protective against global cerebral ischemia in transgenic mice.
Title: Cytochrome P450 2J2 is protective against global cerebral ischemia in transgenic mice.
our findings illustrate a sex-specific role for CYP2J5 in regulation of blood pressure, proximal tubular transport, and afferent arteriolar responsiveness via an estrogen-dependent mechanism.
Title: Increased blood pressure in mice lacking cytochrome P450 2J5.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC291882P3 (e-PCR)
- UniSTS:272442

Cyp2j5 (e-PCR), detects polymorphism
- UniSTS:141450

Cyp2j5 (e-PCR), detects polymorphism
- UniSTS:462999

Results_ER_9_5_95_8.seq (e-PCR)
- UniSTS:125610

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables arachidonate 11,12-epoxygenase activity	ISO Inferred from Sequence Orthology more info
enables arachidonate 14,15-epoxygenase activity	ISO Inferred from Sequence Orthology more info
enables arachidonate epoxygenase activity	ISO Inferred from Sequence Orthology more info
enables heme binding	IBA Inferred from Biological aspect of Ancestor more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables isomerase activity	ISO Inferred from Sequence Orthology more info
enables linoleic acid epoxygenase activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IBA Inferred from Biological aspect of Ancestor more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epoxygenase P450 pathway	ISO Inferred from Sequence Orthology more info
involved_in icosanoid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in linoleic acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in organic acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of estrogen secretion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of systemic arterial blood pressure by hormone	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within renal tubular secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in xenobiotic metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: cytochrome P450 2J5

Names: CYPIIJ5; arachidonic acid epoxygenase; cytochrome P450, 2j5

NP_001405350.1

EC 1.14.14.1

NP_001405351.1

EC 1.14.14.1

NP_034137.1

EC 1.14.14.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001418421.1 → NP_001405350.1 cytochrome P450 2J5 isoform 2

Status: VALIDATED

Source sequence(s)

AL683816

UniProtKB/TrEMBL

Q3UEF7
NM_001418422.1 → NP_001405351.1 cytochrome P450 2J5 isoform 3

Status: VALIDATED

Source sequence(s)

AL683816

UniProtKB/TrEMBL

Q3UEF7
NM_010007.5 → NP_034137.1 cytochrome P450 2J5 isoform 1

See identical proteins and their annotated locations for NP_034137.1

Status: VALIDATED

Source sequence(s)

AL683816

Consensus CDS

CCDS18371.1

UniProtKB/Swiss-Prot

O54749

UniProtKB/TrEMBL

Q3TNC5, Q3UEF7

Related

ENSMUSP00000030299.8, ENSMUST00000030299.8

Conserved Domains (1) summary

pfam00067
Location:44 → 496

p450; Cytochrome P450