Cd300c2 CD300C molecule 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cd300c2provided by MGI
Official Full Name: CD300C molecule 2provided by MGI
Primary source: MGI:MGI:2153249
See related: Ensembl:ENSMUSG00000044811 AllianceGenome:MGI:2153249
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CLM4; CLM-4; DIgR1; Igsf7; Lmir2; Cd300c; Cd300d; MAIR-II
Summary: Predicted to enable transmembrane signaling receptor activity. Acts upstream of or within positive regulation of cytokine production. Located in plasma membrane. Orthologous to human CD300C (CD300c molecule). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in spleen adult (RPKM 14.8), lung adult (RPKM 8.8) and 22 other tissues See more
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Genomic context

Location:: 11 E2; 11 80.57 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (114887595..114892706, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (114996721..115004261, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MAIR-II deficiency ameliorates cardiac remodelling post-myocardial infarction by suppressing TLR9-mediated macrophage activation.
Title: MAIR-II deficiency ameliorates cardiac remodelling post-myocardial infarction by suppressing TLR9-mediated macrophage activation.
Our findings demonstrate that CD300c2 contributes to BLM-induced inflammatory responses mediated by alveolar macrophages.
Title: Cutting Edge: Involvement of the Immunoreceptor CD300c2 on Alveolar Macrophages in Bleomycin-Induced Lung Fibrosis.
Toll-like receptor 4 and MAIR-II/CLM-4/LMIR2 immunoreceptor regulate VLA-4-mediated inflammatory monocyte migration.
Title: Toll-like receptor 4 and MAIR-II/CLM-4/LMIR2 immunoreceptor regulate VLA-4-mediated inflammatory monocyte migration.
DAP12-coupled MAIR-II negatively regulates B cell-mediated adaptive immune responses.
Title: The immunoreceptor adapter protein DAP12 suppresses B lymphocyte-driven adaptive immune responses.
FcRgamma chain may provide cooperation with and/or compensation for DAP12 in MAIR-II-mediated inflammatory responses by peritoneal macrophages
Title: Dual assemblies of an activating immune receptor, MAIR-II, with ITAM-bearing adapters DAP12 and FcRgamma chain on peritoneal macrophages.
structure and tissue distribution
Title: CMRF-35A, CMRF-35H: potential new CD.
Molecular cloning and characterization of leukocyte mono-immunoglobulin-like receptor1 and 2 derived from mast cells [LMIR1] [LMIR2]
Title: Identification and characterization of a new pair of immunoglobulin-like receptors LMIR1 and 2 derived from murine bone marrow-derived mast cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of cytokine production	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: CMRF-35-like molecule 4

Names: CLM; CMRF35-like molecule; Cd300C antigen; Cd300D antigen; MAIR-2; dendritic cell-derived Ig-like receptor 1; dendritic cell-derived immunoglobulin receptor 1; immunoglobulin superfamily, member 7; leukocyte mono-Ig-like receptor 2; myeloid-associated immunoglobulin-like receptor 2; myeloid-associated immunoglobulin-like receptor II

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_134158.2 → NP_598919.1 CMRF-35-like molecule 4 precursor

See identical proteins and their annotated locations for NP_598919.1

Status: VALIDATED

Source sequence(s)

AL607025

Consensus CDS

CCDS25616.1

UniProtKB/Swiss-Prot

Q7TN55, Q7TSN2, Q8JZM5

UniProtKB/TrEMBL

Q2M2Q0

Related

ENSMUSP00000090121.4, ENSMUST00000092464.10

Conserved Domains (1) summary

cd05716
Location:30 → 119

Ig_pIgR_like; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar domains