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    Ubxn7 UBX domain protein 7 [ Mus musculus (house mouse) ]

    Gene ID: 224111, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ubxn7provided by MGI
    Official Full Name
    UBX domain protein 7provided by MGI
    Primary source
    MGI:MGI:2146388
    See related
    Ensembl:ENSMUSG00000053774 AllianceGenome:MGI:2146388
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ubxd7; mKIAA0794; A630090P18
    Summary
    Predicted to enable RNA polymerase II-specific DNA-binding transcription factor binding activity; ubiquitin binding activity; and ubiquitin protein ligase binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in nucleoplasm. Predicted to be part of VCP-NPL4-UFD1 AAA ATPase complex. Predicted to be active in nucleus. Is expressed in several structures, including adrenal gland; gallbladder; genitourinary system; gut; and nervous system. Orthologous to human UBXN7 (UBX domain protein 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 7.1), CNS E11.5 (RPKM 7.0) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ubxn7 in Genome Data Viewer
    Location:
    16 B2- B3; 16 22.58 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (32151023..32212568)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (32332200..32393747)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene ring finger protein 168 Neighboring gene STARR-seq mESC enhancer starr_40655 Neighboring gene STARR-positive B cell enhancer mm9_chr16:32332099-32332400 Neighboring gene predicted gene 8387 Neighboring gene transmembrane 4 L six family member 19 Neighboring gene predicted gene, 20056 Neighboring gene STARR-positive B cell enhancer ABC_E8997 Neighboring gene predicted gene, 53948 Neighboring gene dynein light chain Tctex-type 2B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0794

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of VCP-NPL4-UFD1 AAA ATPase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    UBX domain-containing protein 7
    Names
    UBX domain containing 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001405897.1 → NP_001392826.1  UBX domain-containing protein 7 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC087556, AEKQ02018232
      UniProtKB/Swiss-Prot
      Q6P5G6, Q6ZQ44
      UniProtKB/TrEMBL
      Q3UGV7
      Related
      ENSMUSP00000156376.2, ENSMUST00000232137.2

    2. NM_177633.5 → NP_808301.3  UBX domain-containing protein 7 isoform 1

      See identical proteins and their annotated locations for NP_808301.3

      Status: VALIDATED

      Source sequence(s)
      AC087556, AEKQ02018232
      Consensus CDS
      CCDS49826.1
      UniProtKB/TrEMBL
      G5E8R8, Q3UGV7
      Related
      ENSMUSP00000110804.4, ENSMUST00000115151.5
      Conserved Domains (3) summary
      cd01773
      Location:408 → 489
      Faf1_like1_UBX; Faf1 ike-1 UBX domain
      cd02958
      Location:149 → 261
      UAS; UAS family; UAS is a domain of unknown function. Most members of this family are uncharacterized proteins with similarity to FAS-associated factor 1 (FAF1) and ETEA because of the presence of a UAS domain N-terminal to a ubiquitin-associated UBX domain. ...
      cd14345
      Location:16 → 51
      UBA_UBXD7; UBA-like domain found in UBX domain-containing protein 7 (UBXD7) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      32151023..32212568
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159898.1 → XP_036015791.1  UBX domain-containing protein 7 isoform X4

      Conserved Domains (2) summary
      cd02958
      Location:127 → 239
      UAS; UAS family; UAS is a domain of unknown function. Most members of this family are uncharacterized proteins with similarity to FAS-associated factor 1 (FAF1) and ETEA because of the presence of a UAS domain N-terminal to a ubiquitin-associated UBX domain. ...
      cd14345
      Location:16 → 51
      UBA_UBXD7; UBA-like domain found in UBX domain-containing protein 7 (UBXD7) and similar proteins

    2. XM_011245880.4 → XP_011244182.1  UBX domain-containing protein 7 isoform X3

      Conserved Domains (2) summary
      cd02958
      Location:149 → 261
      UAS; UAS family; UAS is a domain of unknown function. Most members of this family are uncharacterized proteins with similarity to FAS-associated factor 1 (FAF1) and ETEA because of the presence of a UAS domain N-terminal to a ubiquitin-associated UBX domain. ...
      cd14345
      Location:16 → 51
      UBA_UBXD7; UBA-like domain found in UBX domain-containing protein 7 (UBXD7) and similar proteins

    3. XM_036159897.1 → XP_036015790.1  UBX domain-containing protein 7 isoform X2

      UniProtKB/TrEMBL
      Q3UGV7
      Conserved Domains (3) summary
      cd02958
      Location:94 → 206
      UAS; UAS family; UAS is a domain of unknown function. Most members of this family are uncharacterized proteins with similarity to FAS-associated factor 1 (FAF1) and ETEA because of the presence of a UAS domain N-terminal to a ubiquitin-associated UBX domain. ...
      cd01773
      Location:357 → 432
      UBX_UBXN7; Ubiquitin regulatory domain X (UBX) found in UBX domain protein 7 (UBXN7) and similar proteins
      cl21463
      Location:1 → 18
      UBA_like_SF; UBA domain-like superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P5G6.2 GenPept UniProtKB/Swiss-Prot:Q6P5G6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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