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    Cd300e CD300E molecule [ Mus musculus (house mouse) ]

    Gene ID: 217306, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cd300eprovided by MGI
    Official Full Name
    CD300E moleculeprovided by MGI
    Primary source
    MGI:MGI:2387602
    See related
    Ensembl:ENSMUSG00000048498 AllianceGenome:MGI:2387602
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CLM2; TREM5; Cd300le
    Summary
    Predicted to enable transmembrane signaling receptor activity. Predicted to be involved in regulation of innate immune response and signal transduction. Predicted to be active in plasma membrane. Is expressed in ductus deferens; epididymis; and esophagus. Orthologous to human CD300E (CD300e molecule). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in spleen adult (RPKM 2.1), lung adult (RPKM 1.0) and 10 other tissues See more
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    Genomic context

    See Cd300e in Genome Data Viewer
    Location:
    11 E2; 11 80.58 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (114942743..114957502, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (115051917..115066676, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene CD300 molecule like family member D5 Neighboring gene CD300 molecule like family member D3 Neighboring gene STARR-seq mESC enhancer starr_31142 Neighboring gene STARR-seq mESC enhancer starr_31143 Neighboring gene STARR-seq mESC enhancer starr_31145 Neighboring gene STARR-positive B cell enhancer mm9_chr11:114966559-114966859 Neighboring gene RAB37, member RAS oncogene family Neighboring gene STARR-positive B cell enhancer mm9_chr11:114967952-114968253 Neighboring gene CD300 molecule like family member F Neighboring gene STARR-positive B cell enhancer ABC_E11499 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:115019296-115019604 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:115024157-115024344 Neighboring gene STARR-positive B cell enhancer ABC_E91 Neighboring gene NHERF family PDZ scaffold protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    Pathways from PubChem

    General gene information

    Clone Names

    • MGC31495, MGC49720

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function  
    enables transmembrane signaling receptor activity  
    Process Evidence Code Pubs
    involved_in biological_process  
    involved_in immune system process  
    involved_in regulation of innate immune response  
    involved_in signal transduction  
    Component Evidence Code Pubs
    is_active_in plasma membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    CMRF35-like molecule 2
    Names
    CD300 antigen like family member E
    CD300e antigen
    CMRF-35-like molecule-1
    immune receptor expressed on myeloid cells 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172050.3NP_742047.1  CMRF35-like molecule 2 precursor

      See identical proteins and their annotated locations for NP_742047.1

      Status: VALIDATED

      Source sequence(s)
      AL607025
      Consensus CDS
      CCDS25618.1
      UniProtKB/Swiss-Prot
      Q8K249
      Conserved Domains (1) summary
      cd05716
      Location:24126
      Ig_pIgR_like; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar domains

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      114942743..114957502 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006533073.1XP_006533136.1  CMRF35-like molecule 2 isoform X1

      See identical proteins and their annotated locations for XP_006533136.1

      UniProtKB/Swiss-Prot
      Q8K249
      Related
      ENSMUSP00000054883.8, ENSMUST00000062787.9
      Conserved Domains (1) summary
      cd05716
      Location:24126
      Ig_pIgR_like; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar domains
    2. XM_006533074.1XP_006533137.1  CMRF35-like molecule 2 isoform X1

      See identical proteins and their annotated locations for XP_006533137.1

      UniProtKB/Swiss-Prot
      Q8K249
      Conserved Domains (1) summary
      cd05716
      Location:24126
      Ig_pIgR_like; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar domains
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