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    Chn2 chimerin 2 [ Mus musculus (house mouse) ]

    Gene ID: 69993, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Chn2provided by MGI
    Official Full Name
    chimerin 2provided by MGI
    Primary source
    MGI:MGI:1917243
    See related
    Ensembl:ENSMUSG00000004633 AllianceGenome:MGI:1917243
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bch; ARHGAP3; 1700026N20Rik; 4930557O16Rik
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in acrosome assembly. Predicted to be located in synapse. Is expressed in several structures, including central nervous system and retina. Orthologous to human CHN2 (chimerin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 91.1), testis adult (RPKM 53.3) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Chn2 in Genome Data Viewer
    Location:
    6 B3; 6 26.54 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (54016917..54278797)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (54039932..54301812)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_15937 Neighboring gene predicted gene, 33716 Neighboring gene carboxypeptidase, vitellogenic-like Neighboring gene RIKEN cDNA 4921529L05 gene Neighboring gene STARR-seq mESC enhancer starr_15940 Neighboring gene STARR-seq mESC enhancer starr_15942 Neighboring gene RIKEN cDNA 9530036M11 gene Neighboring gene STARR-seq mESC enhancer starr_15947 Neighboring gene 60S ribosomal protein L29 pseudogene Neighboring gene RIKEN cDNA 9130019P16 gene Neighboring gene predicted gene 15527 Neighboring gene STARR-seq mESC enhancer starr_15949 Neighboring gene STARR-seq mESC enhancer starr_15950 Neighboring gene predicted gene, 34169 Neighboring gene proline rich 15 Neighboring gene WAS/WASL interacting protein family, member 3 Neighboring gene predicted gene, 44026

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The RacGAP β-Chimaerin is essential for cerebellar granule cell migration. Estep JA, et al. Sci Rep, 2018 Jan 12. PMID 29330522, Free PMC Article
    2. Diacylglycerol kinase gamma interacts with and activates beta2-chimaerin, a Rac-specific GAP, in response to epidermal growth factor. Yasuda S, et al. FEBS Lett, 2007 Feb 6. PMID 17254573
    3. A new role of the Rac-GAP β2-chimaerin in cell adhesion reveals opposite functions in breast cancer initiation and tumor progression. Casado-Medrano V, et al. Oncotarget, 2016 May 10. PMID 27058424, Free PMC Article
    4. Beta2-chimaerin binds to EphA receptors and regulates cell migration. Takeuchi S, et al. FEBS Lett, 2009 Apr 17. PMID 19306875
    5. α2-Chimaerin is essential for neural stem cell homeostasis in mouse adult neurogenesis. Su YT, et al. Proc Natl Acad Sci U S A, 2019 Jul 2. PMID 31209021, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. essential for neural stem cell homeostasis in mouse adult neurogenesis
      Title: α2-Chimaerin is essential for neural stem cell homeostasis in mouse adult neurogenesis.
    2. our data redefine the role of beta2-chimaerin as tumor suppressor and provide the first in vivo evidence of a dual function in breast cancer, suppressing tumor initiation but favoring tumor progression.
      Title: A new role of the Rac-GAP β2-chimaerin in cell adhesion reveals opposite functions in breast cancer initiation and tumor progression.
    3. Study demonstrates that Sema3F-dependent inhibition of Rac1 by the Rac-GAP beta2Chn is required for hippocampal infrapyramidal tract pruning.
      Title: The RacGAP β2-Chimaerin selectively mediates axonal pruning in the hippocampus.
    4. the Rac-GAP beta2-chimaerin is negatively regulated by protein kinase Cdelta-mediated phosphorylation
      Title: A novel cross-talk in diacylglycerol signaling: the Rac-GAP beta2-chimaerin is negatively regulated by protein kinase Cdelta-mediated phosphorylation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in acrosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    beta-chimaerin
    Names
    Rho GTPase-activating protein 3
    chimerin (chimaerin) 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163640.1 → NP_001157112.1  beta-chimaerin isoform 2

      See identical proteins and their annotated locations for NP_001157112.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate, upstream transcription initiation site, uses a distinct start codon and contains several additional exons, compared to variant 1. The resulting protein (isoform 2, also referred to as beta2-chimerin) has a much longer and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AK131641, BB617538, BB676245, BM935649, BQ175659
      Consensus CDS
      CCDS51778.1
      UniProtKB/TrEMBL
      Q3V2R3
      Related
      ENSMUSP00000035908.8, ENSMUST00000046856.14
      Conserved Domains (3) summary
      cd10352
      Location:52 → 138
      SH2_a2chimerin_b2chimerin; Src homology 2 (SH2) domain found in alpha2-chimerin and beta2-chimerin proteins
      cd04372
      Location:275 → 468
      RhoGAP_chimaerin; RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two ...
      pfam00130
      Location:215 → 267
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    2. NM_001311133.1 → NP_001298062.1  beta-chimaerin isoform 3

      See identical proteins and their annotated locations for NP_001298062.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate 5' terminal exon and initiates translation from an alternate start codon, compared to variant 1. It encodes isoform 3, which is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC084220, AI848376, AK006398, AK131641
      Consensus CDS
      CCDS80535.1
      UniProtKB/TrEMBL
      B9EIU7
      Related
      ENSMUSP00000114476.2, ENSMUST00000146114.8
      Conserved Domains (2) summary
      cd04372
      Location:89 → 282
      RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
      cd20857
      Location:24 → 84
      C1_betaCHN; protein kinase C conserved region 1 (C1 domain) found in beta-chimaerin and similar proteins

    3. NM_001311134.1 → NP_001298063.1  beta-chimaerin isoform 4

      See identical proteins and their annotated locations for NP_001298063.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains an alternate 5' terminal exon and initiates translation from an alternate start codon, compared to variant 1. It encodes isoform 4, which is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC084220, AI848376, AK006398, BU583546
      Consensus CDS
      CCDS80536.1
      UniProtKB/TrEMBL
      B9EIU7, Q3TVA5
      Related
      ENSMUSP00000110043.2, ENSMUST00000114401.8
      Conserved Domains (2) summary
      cd04372
      Location:84 → 277
      RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
      cd20857
      Location:19 → 79
      C1_betaCHN; protein kinase C conserved region 1 (C1 domain) found in beta-chimaerin and similar proteins

    4. NM_023543.2 → NP_076032.2  beta-chimaerin isoform 1

      See identical proteins and their annotated locations for NP_076032.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (1).
      Source sequence(s)
      AK131641, BB676245, BM935649, BQ175659, CX238009
      Consensus CDS
      CCDS20154.1
      UniProtKB/Swiss-Prot
      Q80XD1, Q9D9W2, Q9ER57
      UniProtKB/TrEMBL
      B9EIU7
      Related
      ENSMUSP00000066078.8, ENSMUST00000067741.10
      Conserved Domains (2) summary
      cd04372
      Location:139 → 332
      RhoGAP_chimaerin; RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two ...
      pfam00130
      Location:79 → 131
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      54016917..54278797
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036152294.1 → XP_036008187.1  beta-chimaerin isoform X1

      UniProtKB/TrEMBL
      B9EIU7
      Conserved Domains (2) summary
      cd04372
      Location:129 → 322
      RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
      cd20857
      Location:64 → 124
      C1_betaCHN; protein kinase C conserved region 1 (C1 domain) found in beta-chimaerin and similar proteins

    2. XM_030255589.2 → XP_030111449.1  beta-chimaerin isoform X3

      Conserved Domains (2) summary
      cd04372
      Location:41 → 234
      RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
      cl00040
      Location:1 → 36
      C1; protein kinase C conserved region 1 (C1 domain) superfamily

    3. XM_006506578.4 → XP_006506641.1  beta-chimaerin isoform X2

      See identical proteins and their annotated locations for XP_006506641.1

      UniProtKB/TrEMBL
      B9EIU7, Q3TVA5
      Related
      ENSMUSP00000110044.3, ENSMUST00000114402.9
      Conserved Domains (2) summary
      cd04372
      Location:84 → 277
      RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...
      cd20857
      Location:19 → 79
      C1_betaCHN; protein kinase C conserved region 1 (C1 domain) found in beta-chimaerin and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80XD1.2 GenPept UniProtKB/Swiss-Prot:Q80XD1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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