Acp4 acid phosphatase 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Acp4provided by MGI
Official Full Name: acid phosphatase 4provided by MGI
Primary source: MGI:MGI:3644563
See related: Ensembl:ENSMUSG00000012777 AllianceGenome:MGI:3644563
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Acpt; Gm1432; EG546967
Summary: Predicted to enable acid phosphatase activity; protein tyrosine phosphatase activity; and receptor tyrosine kinase binding activity. Predicted to be involved in several processes, including negative regulation of ERBB4 signaling pathway; negative regulation of protein metabolic process; and regulation of neuronal synaptic plasticity. Predicted to be located in membrane. Predicted to be active in lysosome and postsynaptic membrane. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 1J. Orthologous to human ACP4 (acid phosphatase 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in colon adult (RPKM 27.8), testis adult (RPKM 10.1) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 B3; 7 28.77 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (43901427..43910814, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (44252003..44261390, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Enamel defects in Acp4(R110C/R110C) mice and human ACP4 mutations.
Title: Enamel defects in Acp4(R110C/R110C) mice and human ACP4 mutations.
ACPT inhibits cell proliferation through beta-catenin-mediated signaling in dental mesenchyme but elicits odontoblast differentiation and mineralization by supplying phosphate during dentin formation.
Title: Testicular acid phosphatase induces odontoblast differentiation and mineralization.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables acid phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables acid phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables receptor tyrosine kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables receptor tyrosine kinase binding	ISO Inferred from Sequence Orthology more info
enables receptor tyrosine kinase binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in negative regulation of ERBB4 signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of ERBB4 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ERBB4 signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron projection development	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of protein processing	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein processing	ISS Inferred from Sequence or Structural Similarity more info
involved_in odontogenesis	ISO Inferred from Sequence Orthology more info
involved_in odontogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of neuronal synaptic plasticity	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of neuronal synaptic plasticity	ISO Inferred from Sequence Orthology more info
involved_in regulation of neuronal synaptic plasticity	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in lysosome	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: testicular acid phosphatase

Names: acid phosphatase, testicular

NP_001181963.1

EC 3.1.3.2

NP_001406344.1

EC 3.1.3.2

XP_006540594.1

EC 3.1.3.2

XP_011249074.2

EC 3.1.3.2

XP_017177390.1

EC 3.1.3.2

XP_017177391.1

EC 3.1.3.2

XP_030097791.1

EC 3.1.3.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001195034.1 → NP_001181963.1 testicular acid phosphatase isoform 1 precursor

Status: PROVISIONAL

Source sequence(s)

AC152939

Consensus CDS

CCDS57546.1

UniProtKB/Swiss-Prot

D3YTS9

UniProtKB/TrEMBL

F6WRF1

Related

ENSMUSP00000112922.3, ENSMUST00000118216.8

Conserved Domains (1) summary

cd07061
Location:31 → 315

HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction
NM_001419415.1 → NP_001406344.1 testicular acid phosphatase isoform 2

Status: VALIDATED

Source sequence(s)

AC152939

UniProtKB/TrEMBL

D3YZU0

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

43901427..43910814 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017321901.2 → XP_017177390.1 testicular acid phosphatase isoform X2

UniProtKB/TrEMBL

D3YZU0

Conserved Domains (1) summary

cd07061
Location:32 → 310

HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction
XM_006540531.4 → XP_006540594.1 testicular acid phosphatase isoform X2

UniProtKB/TrEMBL

D3YZU0

Conserved Domains (1) summary

cd07061
Location:32 → 310

HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction
XM_017321902.3 → XP_017177391.1 testicular acid phosphatase isoform X3

UniProtKB/TrEMBL

D3YZU0

Related

ENSMUSP00000103578.2, ENSMUST00000107945.8

Conserved Domains (1) summary

cd07061
Location:23 → 301

HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction
XM_030241931.2 → XP_030097791.1 testicular acid phosphatase isoform X5

Conserved Domains (1) summary

cd07061
Location:54 → 333

HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction
XM_011250772.3 → XP_011249074.2 testicular acid phosphatase isoform X4

UniProtKB/TrEMBL

F6WRF1

Conserved Domains (1) summary

cd07061
Location:54 → 333

HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction