Ifnl3 interferon lambda 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ifnl3provided by MGI
Official Full Name: interferon lambda 3provided by MGI
Primary source: MGI:MGI:2450574
See related: Ensembl:ENSMUSG00000060747 AllianceGenome:MGI:2450574
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Il28; IFL-1; Il28b; IL-28B; If1ia2; INF-alpha; INF-lambda
Summary: Predicted to enable interleukin-28 receptor binding activity. Acts upstream of or within innate immune response. Located in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including COVID-19; cryoglobulinemia; dengue hemorrhagic fever; hepatitis C; and liver disease (multiple). Orthologous to several human genes including IFNL2 (interferon lambda 2) and IFNL3 (interferon lambda 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in adrenal adult (RPKM 1.2), thymus adult (RPKM 0.2) and 2 other tissues See more
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Genomic context

Location:: 7 A3; 7 16.81 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (28222251..28223826)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (28522833..28524401)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IFN-lambda3 is induced by Leishmania donovani and can inhibit parasite growth in cell line models but not in the mouse model, while it shows a significant association with leishmaniasis in humans.
Title: IFN-λ3 is induced by Leishmania donovani and can inhibit parasite growth in cell line models but not in the mouse model, while it shows a significant association with leishmaniasis in humans.
Interleukin-28B dampens protease-induced lung inflammation via IL-25 and TSLP inhibition in epithelial cells.
Title: Interleukin-28B dampens protease-induced lung inflammation via IL-25 and TSLP inhibition in epithelial cells.
Protective cellular and mucosal immune responses following nasal administration of a whole gamma-irradiated influenza A (subtype H1N1) vaccine adjuvanted with interleukin-28B in a mouse model.
Title: Protective cellular and mucosal immune responses following nasal administration of a whole gamma-irradiated influenza A (subtype H1N1) vaccine adjuvanted with interleukin-28B in a mouse model.
Selective Interferon Responses of Intestinal Epithelial Cells Minimize Tumor Necrosis Factor Alpha Cytotoxicity.
Title: Selective Interferon Responses of Intestinal Epithelial Cells Minimize Tumor Necrosis Factor Alpha Cytotoxicity.
Type I and III interferons disrupt lung epithelial repair during recovery from viral infection.
Title: Type I and III interferons disrupt lung epithelial repair during recovery from viral infection.
Type III interferons disrupt the lung epithelial barrier upon viral recognition.
Title: Type III interferons disrupt the lung epithelial barrier upon viral recognition.
IFN-lambda Decreases Murid Herpesvirus-4 Infection of the Olfactory Epithelium but Fails to Prevent Virus Reactivation in the Vaginal Mucosa.
Title: IFN-λ Decreases Murid Herpesvirus-4 Infection of the Olfactory Epithelium but Fails to Prevent Virus Reactivation in the Vaginal Mucosa.
Results support the idea of an exclusive role for known type III interferon cytokines in signaling via IFNLR to mediate antiviral effects at mucosal surfaces. These findings emphasize the importance of type III interferons in regulation of a variety of viral pathogens and provide important genetic evidence to support our understanding of the ligand-receptor interactions in this pathway.
Title: Disruption of Type III Interferon (IFN) Genes Ifnl2 and Ifnl3 Recapitulates Loss of the Type III IFN Receptor in the Mucosal Antiviral Response.
Study provides evidence that interferon-l3 promotes intestinal epithelial cell defense against Cryptosporidium parvum by inhibiting parasite invasion and mitigating loss of paracellular barrier function.
Title: Interferon-λ3 Promotes Epithelial Defense and Barrier Function Against Cryptosporidium parvum Infection.
The KH-type splicing regulatory protein (KSRP) regulates type III interferon expression post-transcriptionally.
Title: The KH-type splicing regulatory protein (KSRP) regulates type III interferon expression post-transcriptionally.

Submit: New GeneRIF Correction See all GeneRIFs (26)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation
Targeted (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables interleukin-28 receptor binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	ISA Inferred from Sequence Alignment more info	PubMed
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell surface receptor signaling pathway via JAK-STAT	IEA Inferred from Electronic Annotation more info
involved_in defense response to virus	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to virus	ISS Inferred from Sequence or Structural Similarity more info
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within innate immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of viral genome replication	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of immune response	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
part_of interleukin-28 receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: interferon lambda-3

Names: IFN-lambda-3; interferon 1ia2; interferon alpha; interleukin 28; interleukin-28B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_177396.1 → NP_796370.1 interferon lambda-3 precursor

See identical proteins and their annotated locations for NP_796370.1

Status: PROVISIONAL

Source sequence(s)

AY184375

Consensus CDS

CCDS21047.1

UniProtKB/Swiss-Prot

Q4VK73, Q8CGK6

UniProtKB/TrEMBL

B9EK98

Related

ENSMUSP00000077473.4, ENSMUST00000078364.4

Conserved Domains (1) summary

pfam15177
Location:32 → 189

IL28A; Interleukin-28A

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

28222251..28223826

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006540130.2 → XP_006540193.1 interferon lambda-3 isoform X1

Conserved Domains (2) summary

PRK14971
Location:58 → 240

PRK14971; DNA polymerase III subunit gamma/tau

pfam15177
Location:32 → 142

IL28A; Interleukin-28A