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    Lrrc1 leucine rich repeat containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 214345, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lrrc1provided by MGI
    Official Full Name
    leucine rich repeat containing 1provided by MGI
    Primary source
    MGI:MGI:2442313
    See related
    Ensembl:ENSMUSG00000032352 AllianceGenome:MGI:2442313
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA4018; D030059I21; A430093J20Rik
    Summary
    Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to human LRRC1 (leucine rich repeat containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis adult (RPKM 34.3), large intestine adult (RPKM 18.7) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Lrrc1 in Genome Data Viewer
    Location:
    9 D; 9 43.36 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (77338103..77453749, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (77430821..77546464, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene muscular LMNA-interacting protein Neighboring gene predicted gene, 53504 Neighboring gene RIKEN cDNA 5730403I07 gene Neighboring gene STARR-positive B cell enhancer mm9_chr9:77234587-77234888 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:77317674-77317857 Neighboring gene STARR-seq mESC enhancer starr_24696 Neighboring gene STARR-seq mESC enhancer starr_24697 Neighboring gene STARR-seq mESC enhancer starr_24699 Neighboring gene STARR-positive B cell enhancer mm9_chr9:77398917-77399217 Neighboring gene STARR-seq mESC enhancer starr_24700 Neighboring gene chimerin (chimaerin) 1 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:77440338-77440521 Neighboring gene STARR-positive B cell enhancer ABC_E2905 Neighboring gene STARR-seq mESC enhancer starr_24701 Neighboring gene STARR-seq mESC enhancer starr_24702 Neighboring gene STARR-positive B cell enhancer ABC_E6770 Neighboring gene kelch-like 31

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. LAP proteins are localized at the post-synaptic membrane of neuromuscular junctions and appear to modulate synaptic morphology and transmission. Kravic B, et al. J Neurochem, 2016 Nov. PMID 27321929
    2. The Upregulation of Leucine-Rich Repeat Containing 1 Expression Activates Hepatic Stellate Cells and Promotes Liver Fibrosis by Stabilizing Phosphorylated Smad2/3. Wang Y, et al. Int J Mol Sci, 2024 Feb 27. PMID 38473980, Free PMC Article
    3. Short-lived AUF1 p42-binding mRNAs of RANKL and BCL6 have two distinct instability elements each. Dogar AM, et al. PLoS One, 2018. PMID 30418981, Free PMC Article
    4. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article
    5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Upregulation of Leucine-Rich Repeat Containing 1 Expression Activates Hepatic Stellate Cells and Promotes Liver Fibrosis by Stabilizing Phosphorylated Smad2/3.
      Title: The Upregulation of Leucine-Rich Repeat Containing 1 Expression Activates Hepatic Stellate Cells and Promotes Liver Fibrosis by Stabilizing Phosphorylated Smad2/3.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA4018, MGC90936

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001146048.1 → NP_001139520.1  leucine-rich repeat-containing protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001139520.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK220166
      Consensus CDS
      CCDS72282.1
      UniProtKB/Swiss-Prot
      Q3UI50, Q80VQ1, Q8BKR1, Q8BUS9
      UniProtKB/TrEMBL
      Q571M3
      Related
      ENSMUSP00000139226.2, ENSMUST00000183873.8
      Conserved Domains (2) summary
      sd00033
      Location:61 → 83
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:36 → 94
      LRR_8; Leucine rich repeat

    2. NM_172528.3 → NP_766116.3  leucine-rich repeat-containing protein 1 isoform 2

      See identical proteins and their annotated locations for NP_766116.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate exon at the 5' end and uses a different start codon, compared to variant 1. These differences result in an isoform (2) with a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK082721, AK220166
      Consensus CDS
      CCDS52862.1
      UniProtKB/TrEMBL
      G3X9W3
      Related
      ENSMUSP00000109048.3, ENSMUST00000113421.10
      Conserved Domains (2) summary
      sd00033
      Location:16 → 38
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:84 → 141
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      77338103..77453749 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030244218.2 → XP_030100078.1  leucine-rich repeat-containing protein 1 isoform X1

      Conserved Domains (3) summary
      COG4886
      Location:146 → 446
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      PRK12323
      Location:4 → 158
      PRK12323; DNA polymerase III subunit gamma/tau
      sd00033
      Location:163 → 185
      LRR_RI; leucine-rich repeat [structural motif]

    2. XM_036154820.1 → XP_036010713.1  leucine-rich repeat-containing protein 1 isoform X2

      Conserved Domains (2) summary
      PRK15370
      Location:36 → 270
      PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
      sd00033
      Location:3 → 25
      LRR_RI; leucine-rich repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80VQ1.2 GenPept UniProtKB/Swiss-Prot:Q80VQ1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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