Ube3d ubiquitin protein ligase E3D [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ube3dprovided by MGI
Official Full Name: ubiquitin protein ligase E3Dprovided by MGI
Primary source: MGI:MGI:1917598
See related: Ensembl:ENSMUSG00000032415 AllianceGenome:MGI:1917598
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ube2cbp; 2610018I03Rik
Summary: Predicted to enable cyclin binding activity; ubiquitin conjugating enzyme binding activity; and ubiquitin protein ligase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein ubiquitination. Predicted to be located in cytoplasm. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytosol and nucleus. Orthologous to human UBE3D (ubiquitin protein ligase E3D). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 1.4), CNS E14 (RPKM 1.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 E3.1; 9 46.58 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (86189364..86347003, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (86307234..86464976, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Conditional loss of Ube3d in the retinal pigment epithelium accelerates age-associated alterations in the retina of mice.
Title: Conditional loss of Ube3d in the retinal pigment epithelium accelerates age-associated alterations in the retina of mice.
UBE3D Regulates mRNA 3'-End Processing and Maintains Adipogenic Potential in 3T3-L1 Cells.
Title: UBE3D Regulates mRNA 3'-End Processing and Maintains Adipogenic Potential in 3T3-L1 Cells.
UBE3D Is Involved in Blue Light-Induced Retinal Damage by Regulating Double-Strand Break Repair.
Title: UBE3D Is Involved in Blue Light-Induced Retinal Damage by Regulating Double-Strand Break Repair.
Ablation of the UBE3D protein lead to an abnormal amount of pigment granules deposited in retinal pigment epithelium microvilli area and an abnormal response on electroretinography (ERG) in UBE3D(+/-) heterozygous mice.
Title: Whole-exome sequencing implicates UBE3D in age-related macular degeneration in East Asian populations.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation

General gene information

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Markers

RH101866 (e-PCR)
- UniSTS:116773

NoName (e-PCR)
- UniSTS:488813

NoName (e-PCR)
- UniSTS:236211

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cyclin binding	IBA Inferred from Biological aspect of Ancestor more info
enables cyclin binding	IEA Inferred from Electronic Annotation more info
enables cyclin binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin conjugating enzyme binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-like protein conjugating enzyme binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin-like protein conjugating enzyme binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein autoubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein autoubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein autoubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein monoubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein monoubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein monoubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein polyubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein polyubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein polyubiquitination	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ubiquitin ligase complex	IEA Inferred from Electronic Annotation more info
part_of ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase E3D

Names: HECT-type E3 ubiquitin transferase E3D; UbcH10 binding protein with a hect-like domain; ubcH10-binding protein with a HECT-like domain; ubiquitin-conjugating enzyme E2C binding protein

NP_001405800.1

EC 2.3.2.26

NP_001405801.1

EC 2.3.2.26

NP_001405802.1

EC 2.3.2.26

NP_081670.1

EC 2.3.2.26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001418871.1 → NP_001405800.1 E3 ubiquitin-protein ligase E3D isoform 2

Status: VALIDATED

Source sequence(s)

AC137556, AC157998

UniProtKB/TrEMBL

Q9D0H0
NM_001418872.1 → NP_001405801.1 E3 ubiquitin-protein ligase E3D isoform 3

Status: VALIDATED

Source sequence(s)

AC137556, AC157998
NM_001418873.1 → NP_001405802.1 E3 ubiquitin-protein ligase E3D isoform 4

Status: VALIDATED

Source sequence(s)

AC137556, AC157998
NM_001433775.1 → NP_001420704.1 E3 ubiquitin-protein ligase E3D isoform 5

Status: VALIDATED

Source sequence(s)

AC137556, AC157998
NM_027394.3 → NP_081670.1 E3 ubiquitin-protein ligase E3D isoform 1

See identical proteins and their annotated locations for NP_081670.1

Status: VALIDATED

Source sequence(s)

AC137556, AC157998

Consensus CDS

CCDS40713.1

UniProtKB/Swiss-Prot

Q8BX13

UniProtKB/TrEMBL

Q9D0H0

Related

ENSMUSP00000034986.8, ENSMUST00000034986.14

Conserved Domains (1) summary

pfam09814
Location:13 → 358

HECT_2; HECT-like Ubiquitin-conjugating enzyme (E2)-binding