Hgfac hepatocyte growth factor activator [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hgfacprovided by MGI
Official Full Name: hepatocyte growth factor activatorprovided by MGI
Primary source: MGI:MGI:1859281
See related: Ensembl:ENSMUSG00000029102 AllianceGenome:MGI:1859281
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: HGFA
Summary: This gene encodes a serine protease enzyme that proteolytically activates hepatocyte growth factor (HGF) and plays a vital role in the regulation of HGF activity in the regeneration and repair of various tissues. The encoded protein is an inactive zymogen that is proteolytically activated to generate a heterodimeric enzyme consisting of a short chain and a long chain linked by a disulfide bridge. Mice lacking the encoded protein display an impairment in mucosal regeneration after injury. [provided by RefSeq, Jul 2015]
Expression: Biased expression in colon adult (RPKM 227.5), liver adult (RPKM 215.9) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 B2; 5 17.99 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (35198853..35205805)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (35041509..35048461)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HGFAC is a ChREBP-regulated hepatokine that enhances glucose and lipid homeostasis.
Title: HGFAC is a ChREBP-regulated hepatokine that enhances glucose and lipid homeostasis.
HNF1alpha might regulate beta-cell mass or function at least partly by modulating Hgfac expression.
Title: Identification of hepatocyte growth factor activator (Hgfac) gene as a target of HNF1α in mouse β-cells.
HGFA is required for repair of injured intestinal mucosa but is not essential for normal development during embryogenesis or after birth.
Title: Regeneration of injured intestinal mucosa is impaired in hepatocyte growth factor activator-deficient mice.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Targeted (2) 1 citation

General gene information

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Markers

AI042655 (e-PCR)
- UniSTS:159364

RH66538 (e-PCR)
- UniSTS:91646

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in blood coagulation	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in zymogen activation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
is_active_in rough endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in rough endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: hepatocyte growth factor activator

Names: HGF activator

NP_062320.2

EC 3.4.21.-

XP_006504094.1

EC 3.4.21.-

XP_006504095.1

EC 3.4.21.-

XP_006504096.1

EC 3.4.21.-

XP_030110566.1

EC 3.4.21.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019447.3 → NP_062320.2 hepatocyte growth factor activator preproprotein

See identical proteins and their annotated locations for NP_062320.2

Status: REVIEWED

Source sequence(s)

AK149522, AK165433, BY195777

Consensus CDS

CCDS19223.1

UniProtKB/Swiss-Prot

Q9JKV4, Q9R098

UniProtKB/TrEMBL

Q545J3, Q8VCS4

Related

ENSMUSP00000030985.7, ENSMUST00000030985.10

Conserved Domains (6) summary

smart00059
Location:99 → 145

FN2; Fibronectin type 2 domain

smart00020
Location:405 → 639

Tryp_SPc; Trypsin-like serine protease

cd00054
Location:159 → 194

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00061
Location:197 → 237

FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...

cd00190
Location:406 → 641

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

pfam00051
Location:283 → 364

Kringle; Kringle domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

35198853..35205805

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006504031.3 → XP_006504094.1 hepatocyte growth factor activator isoform X1

UniProtKB/TrEMBL

Q8VCS4

Conserved Domains (5) summary

smart00059
Location:99 → 145

FN2; Fibronectin type 2 domain

cd00054
Location:159 → 194

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00061
Location:197 → 237

FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...

cd00190
Location:406 → 646

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

pfam00051
Location:283 → 364

Kringle; Kringle domain
XM_006504032.3 → XP_006504095.1 hepatocyte growth factor activator isoform X2

UniProtKB/TrEMBL

Q8VCS4

Conserved Domains (4) summary

smart00059
Location:99 → 145

FN2; Fibronectin type 2 domain

cd00054
Location:159 → 194

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00190
Location:362 → 602

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

pfam00051
Location:239 → 320

Kringle; Kringle domain
XM_030254706.1 → XP_030110566.1 hepatocyte growth factor activator isoform X3

UniProtKB/TrEMBL

Q8VCS4

Conserved Domains (4) summary

smart00059
Location:99 → 145

FN2; Fibronectin type 2 domain

cd00054
Location:159 → 194

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00190
Location:362 → 597

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

pfam00051
Location:239 → 320

Kringle; Kringle domain
XM_006504033.1 → XP_006504096.1 hepatocyte growth factor activator isoform X4

Conserved Domains (4) summary

smart00059
Location:99 → 145

FN2; Fibronectin type 2 domain

cd00054
Location:159 → 194

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00061
Location:197 → 237

FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...

pfam00051
Location:283 → 364

Kringle; Kringle domain