Slc34a1 solute carrier family 34 member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc34a1provided by RGD
Official Full Name: solute carrier family 34 member 1provided by RGD
Primary source: RGD:3708
See related: EnsemblRapid:ENSRNOG00000015262 AllianceGenome:RGD:3708
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Npt2; NaPi-2; NaPi2A; Slc17a2
Summary: Enables PDZ domain binding activity; identical protein binding activity; and sodium:phosphate symporter activity. Involved in several processes, including arsenate ion transmembrane transport; phosphate ion transport; and regulation of phosphate transport. Located in several cellular components, including apical plasma membrane; brush border membrane; and perinuclear region of cytoplasm. Biomarker of autosomal dominant polycystic kidney disease; chronic kidney disease (multiple); hyperthyroidism; hypophosphatemia; and hypothyroidism. Human ortholog(s) of this gene implicated in several diseases, including Fanconi syndrome (multiple); chronic kidney disease; hereditary hypophosphatemic rickets with hypercalciuria; hypophosphatemic nephrolithiasis/osteoporosis 1; and nephrolithiasis. Orthologous to human SLC34A1 (solute carrier family 34 member 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 4338.1) See more
Orthologs: human mouse all
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Genomic context

Location:: 17p14

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (9224010..9238983, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (9218876..9233852, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (9747766..9762739, complement)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Selective pharmacological inhibition of the sodium-dependent phosphate cotransporter NPT2a promotes phosphate excretion.
Title: Selective pharmacological inhibition of the sodium-dependent phosphate cotransporter NPT2a promotes phosphate excretion.
multiprotein kinase cascade involving G protein-coupled receptor kinase 6A controls the Ser(290) phosphorylation status of NHERF1 and regulates PTH-sensitive, NPT2A-mediated phosphate uptake
Title: Parathyroid hormone initiates dynamic NHERF1 phosphorylation cycling and conformational changes that regulate NPT2A-dependent phosphate transport.
Napi2a, a renal cotransporter for Pi reabsorption, accumulated on plasma membranes in a vitamin B12 deficiency suggests that vitamin B12 plays an important role in Pi homeostasis
Title: Vitamin B₁₂ deficiency-induced increase of osteoclastic bone resorption caused by abnormal renal resorption of inorganic phosphorus via Napi2a.
NaPi-IIa mRNA expression is affected by hyperphosphatemia.
Title: Effect of hyperphosphatemia on gene expression of the Na-Pi cotransporter in rats.
Estrogen induces phosphaturia by directly and specifically targeting NaPi-IIa in the proximal tubule cells.
Title: Estrogen directly and specifically downregulates NaPi-IIa through the activation of both estrogen receptor isoforms (ERα and ERβ) in rat kidney proximal tubule.
Magnesium deficiency induces downregulation of 1alpha(OH)ase and type IIa and IIc Na/Pi cotransporters, and upregulation of 24(OH)ase in the kidney.
Title: Magnesium deficiency regulates vitamin D metabolizing enzymes and type II sodium-phosphate cotransporter mRNA expression in rats.
Downregulation of renal Npt2a expression through induction of plasma iPTH levels alters Pi homeostasis during LPS-induced acute inflammation.
Title: Downregulation of renal type IIa sodium-dependent phosphate cotransporter during lipopolysaccharide-induced acute inflammation.
NaPi-2a transporter expression in the trans-Golgi network and its interaction with PIST in the proximal tubule is modulated by inorganic phosphate
Title: Inorganic phosphate modulates the expression of the NaPi-2a transporter in the trans-Golgi network and the interaction with PIST in the proximal tubule.
We demonstrated a progressive decrease in brush-border membrane (BBM) expression of Npt2a from rats treated with PTH for 6 h or 4 days.
Title: Parathyroid hormone (PTH) decreases sodium-phosphate cotransporter type IIa (NpT2a) mRNA stability.
PFA decreased iPTH level but had no effect on NaPi-2 mRNA expression. Renagel decreased serum P and iPTH levels, but upregulated renal NaPi-2 mRNA expression.
Title: Effects of phosphonoformic acid and renagel on renal type IIa sodium-dependent phosphate cotransporter mRNA expression in hyperphosphatemia rats.

Submit: New GeneRIF Correction See all GeneRIFs (24)

General gene information

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Markers

Slc34a1 (e-PCR), detects polymorphism
- UniSTS:260829

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables PDZ domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables sodium:phosphate symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables sodium:phosphate symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables sodium:phosphate symporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables sodium:phosphate symporter activity	ISO Inferred from Sequence Orthology more info
enables sodium:phosphate symporter activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in arsenate ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within bone remodeling	ISO Inferred from Sequence Orthology more info
involved_in calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in cellular response to metal ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to parathyroid hormone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to phosphate starvation	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to staurosporine	IEP Inferred from Expression Pattern more info	PubMed
involved_in dentinogenesis	IEP Inferred from Expression Pattern more info	PubMed
involved_in gene expression	ISO Inferred from Sequence Orthology more info
involved_in gentamycin metabolic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in glycoprotein metabolic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in indole metabolic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in inorganic diphosphate transport	ISO Inferred from Sequence Orthology more info
involved_in intracellular phosphate ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in kidney development	IEP Inferred from Expression Pattern more info	PubMed
involved_in ossification	IEP Inferred from Expression Pattern more info	PubMed
involved_in phosphate ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in phosphate ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphate ion transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of membrane potential	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phosphate transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of sodium-dependent phosphate transport	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of sodium-dependent phosphate transport	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of sodium-dependent phosphate transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to cadmium ion	ISO Inferred from Sequence Orthology more info
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to growth hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lead ion	ISO Inferred from Sequence Orthology more info
involved_in response to magnesium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to mercury ion	ISO Inferred from Sequence Orthology more info
involved_in response to nutrient	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to parathyroid hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to peptide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to peptide hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to potassium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to sodium phosphate	ISO Inferred from Sequence Orthology more info
involved_in response to thyroid hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to vitamin A	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in sodium ion import across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in sodium-dependent phosphate transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in sodium-dependent phosphate transport	IEP Inferred from Expression Pattern more info	PubMed
involved_in tricarboxylic acid metabolic process	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in brush border	IBA Inferred from Biological aspect of Ancestor more info
located_in brush border membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in mitotic spindle	IEA Inferred from Electronic Annotation more info
located_in mitotic spindle	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sodium-dependent phosphate transport protein 2A

Names: Na(+)-dependent phosphate cotransporter 2A; Na(+)/Pi cotransporter 2A; naPi-2a; sodium-phosphate co-transporter type II; sodium-phosphate transport protein 2A; sodium/phosphate cotransporter 2A; solute carrier family 17 (sodium/hydrogen exchanger) member 2; solute carrier family 34 (sodium phosphate), member 1; solute carrier family 34 (type II sodium/phosphate cotransporter), member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.