Dhcr7 7-dehydrocholesterol reductase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dhcr7provided by RGD
Official Full Name: 7-dehydrocholesterol reductaseprovided by RGD
Primary source: RGD:621769
See related: EnsemblRapid:ENSRNOG00000020776 AllianceGenome:RGD:621769
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables 7-dehydrocholesterol reductase activity. Involved in cholesterol biosynthetic process and regulation of cholesterol biosynthetic process. Predicted to be located in endoplasmic reticulum and nuclear outer membrane. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in Behcet's disease and Smith-Lemli-Opitz syndrome. Orthologous to human DHCR7 (7-dehydrocholesterol reductase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 460.5), Liver (RPKM 232.8) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q42

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (208444434..208460408)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (199015081..199031055)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (217018916..217034890)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Effect of DHCR7 for the co-occurrence of hypercholesterolemia and vitamin D deficiency in type 2 diabetes: Perspective of health prevention.
Title: Effect of DHCR7 for the co-occurrence of hypercholesterolemia and vitamin D deficiency in type 2 diabetes: Perspective of health prevention.
gene structure and alternative splicing
Title: Structure and alternative splicing of the rat 7-dehydrocholesterol reductase gene.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 7-dehydrocholesterol reductase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 7-dehydrocholesterol reductase activity	IEA Inferred from Electronic Annotation more info
enables 7-dehydrocholesterol reductase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables 7-dehydrocholesterol reductase activity	ISO Inferred from Sequence Orthology more info
enables 7-dehydrocholesterol reductase activity	TAS Traceable Author Statement more info	PubMed
enables NADP binding	ISS Inferred from Sequence or Structural Similarity more info
enables cholesterol-5,6-oxide hydrolase activity	ISO Inferred from Sequence Orthology more info
enables cholesterol-5,6-oxide hydrolase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within blood vessel development	ISO Inferred from Sequence Orthology more info
involved_in cholesterol biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in cholesterol biosynthetic process	IC Inferred by Curator more info	PubMed
involved_in cholesterol biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in cholesterol biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cholesterol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in cholesterol biosynthetic process	TAS Traceable Author Statement more info	PubMed
involved_in cholesterol biosynthetic process via lathosterol	IEA Inferred from Electronic Annotation more info
involved_in cholesterol biosynthetic process via lathosterol	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lung development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lung epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within multicellular organism growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ferroptosis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ferroptosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within post-embryonic development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of cholesterol biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within sterol biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear outer membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear outer membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: 7-dehydrocholesterol reductase

Names: 7-DHC reductase; sterol Delta(7)-reductase

NP_071784.1

EC 1.3.1.21

XP_006230955.1

EC 1.3.1.21

XP_006230956.1

EC 1.3.1.21

XP_038945428.1

EC 1.3.1.21

XP_063128807.1

EC 1.3.1.21

XP_063128808.1

EC 1.3.1.21

XP_063128809.1

EC 1.3.1.21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022389.3 → NP_071784.1 7-dehydrocholesterol reductase

See identical proteins and their annotated locations for NP_071784.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

Q9Z2Z8

UniProtKB/TrEMBL

A0A8L2R4U0, A6HYE0

Related

ENSRNOP00000028194.3, ENSRNOT00000028195.7

Conserved Domains (1) summary

cl21511
Location:89 → 471

PEMT; Phospholipid methyltransferase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

208444434..208460408

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063272737.1 → XP_063128807.1 7-dehydrocholesterol reductase isoform X1

UniProtKB/Swiss-Prot

Q9Z2Z8

UniProtKB/TrEMBL

A0A8L2R4U0, A6HYE0
XM_006230893.5 → XP_006230955.1 7-dehydrocholesterol reductase isoform X1

See identical proteins and their annotated locations for XP_006230955.1

UniProtKB/Swiss-Prot

Q9Z2Z8

UniProtKB/TrEMBL

A0A8L2R4U0, A6HYE0

Related

ENSRNOP00000071939.2, ENSRNOT00000078979.3

Conserved Domains (1) summary

cl21511
Location:89 → 471

PEMT; Phospholipid methyltransferase
XM_039089500.2 → XP_038945428.1 7-dehydrocholesterol reductase isoform X1

UniProtKB/Swiss-Prot

Q9Z2Z8

UniProtKB/TrEMBL

A0A8L2R4U0, A6HYE0

Conserved Domains (1) summary

cl21511
Location:89 → 471

PEMT; Phospholipid methyltransferase
XM_006230894.5 → XP_006230956.1 7-dehydrocholesterol reductase isoform X1

See identical proteins and their annotated locations for XP_006230956.1

UniProtKB/Swiss-Prot

Q9Z2Z8

UniProtKB/TrEMBL

A0A8L2R4U0, A6HYE0

Conserved Domains (1) summary

cl21511
Location:89 → 471

PEMT; Phospholipid methyltransferase
XM_063272739.1 → XP_063128809.1 7-dehydrocholesterol reductase isoform X1

UniProtKB/Swiss-Prot

Q9Z2Z8

UniProtKB/TrEMBL

A0A8L2R4U0, A6HYE0
XM_063272738.1 → XP_063128808.1 7-dehydrocholesterol reductase isoform X1

UniProtKB/Swiss-Prot

Q9Z2Z8

UniProtKB/TrEMBL

A0A8L2R4U0, A6HYE0