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    Kcnn1 potassium calcium-activated channel subfamily N member 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 54261, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Kcnn1provided by RGD
    Official Full Name
    potassium calcium-activated channel subfamily N member 1provided by RGD
    Primary source
    RGD:2962
    See related
    EnsemblRapid:ENSRNOG00000029264 AllianceGenome:RGD:2962
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    SK1; SKCa1; KCa2.1
    Summary
    Enables small conductance calcium-activated potassium channel activity. Predicted to be involved in potassium ion transmembrane transport. Located in neuronal cell body. Orthologous to human KCNN1 (potassium calcium-activated channel subfamily N member 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 27.2), Heart (RPKM 11.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Kcnn1 in Genome Data Viewer
    Location:
    16p14
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (18608782..18632571)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (18574858..18598585)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (20325270..20349163)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 5 member 5 Neighboring gene uncharacterized LOC134482469 Neighboring gene coiled-coil domain containing 124 Neighboring gene uncharacterized LOC134482468 Neighboring gene arrestin domain containing 2 Neighboring gene interleukin 12 receptor subunit beta 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Firing pattern modulation through SK channel current increase underlies neuronal survival in an organotypic slice model of Parkinson's disease. Wang Y, et al. Mol Neurobiol, 2015 Feb. PMID 24841382
    2. Role of small conductance calcium-activated potassium channels expressed in PVN in regulating sympathetic nerve activity and arterial blood pressure in rats. Gui L, et al. Am J Physiol Regul Integr Comp Physiol, 2012 Aug 1. PMID 22647293, Free PMC Article
    3. Domain analysis of the calcium-activated potassium channel SK1 from rat brain. Functional expression and toxin sensitivity. D'hoedt D, et al. J Biol Chem, 2004 Mar 26. PMID 14761961
    4. Depletion of SK1 channel subunits leads to constitutive insulin secretion. Andres MA, et al. FEBS Lett, 2009 Jan 22. PMID 19101546
    5. rSK1 in Rat Neurons: A Controller of Membrane rSK2? Autuori E, et al. Front Neural Circuits, 2019. PMID 31001092, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. these results indicate that ADSC-derived exosomes ameliorate cardiac damage after MI by activating S1P/SK1/S1PR1 signaling and promoting macrophage M2 polarization.
      Title: Exosomes from adipose-derived mesenchymal stem cells ameliorate cardiac damage after myocardial infarction by activating S1P/SK1/S1PR1 signaling and promoting macrophage M2 polarization.
    2. rSK1 appears to act as chaperone for rSK2 channels and expression of rSK1 may control the level of functional SK current in rat neurons.
      Title: rSK1 in Rat Neurons: A Controller of Membrane rSK2?
    3. SK channel current is a substantial element in sustaining the substantia nigra pars compacta dopaminergic neuroal rhythmic pacemaking.
      Title: Firing pattern modulation through SK channel current increase underlies neuronal survival in an organotypic slice model of Parkinson's disease.
    4. This study demonistrated that SK1 and SK2 transcripts showed strong expression starting from E15 in the striatum and decreased throughout pre- and postnatal development.
      Title: Developmental mapping of small-conductance calcium-activated potassium channel expression in the rat nervous system.
    5. Small conductance Ca(2+)-activated K(+) (SK) channels expressed in the hypothalamic paraventricular nucleus play an important role in the regulation of sympathetic outflow and cardiovascular function.
      Title: Role of small conductance calcium-activated potassium channels expressed in PVN in regulating sympathetic nerve activity and arterial blood pressure in rats.
    6. expressed in myometrium throughout pregnancy and contribute to outward current, regulate membrane potential and calcium signalling
      Title: Distribution, expression and functional effects of small conductance Ca-activated potassium (SK) channels in rat myometrium.
    7. downregulation of SK1 and SK3 channels and upregulation of SK2 channels provide direct evidence that these Ca2+-activated K+ channels play important roles in inferior colliculi neuronal hyperexcitability that leads to inherited seizure susceptibility
      Title: Protein expression of small conductance calcium-activated potassium channels is altered in inferior colliculus neurons of the genetically epilepsy-prone rat.
    8. These results implicate SK1 subunits as key regulators of excitability and endocrine function in beta cells.
      Title: Depletion of SK1 channel subunits leads to constitutive insulin secretion.
    9. rSK1 subunit is synthesized in cells but does not form functional homomeric channels
      Title: Domain analysis of the calcium-activated potassium channel SK1 from rat brain. Functional expression and toxin sensitivity.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables inward rectifier potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inward rectifier potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-containing complex binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables small conductance calcium-activated potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables small conductance calcium-activated potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables small conductance calcium-activated potassium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables small conductance calcium-activated potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small conductance calcium-activated potassium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Z disc IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    small conductance calcium-activated potassium channel protein 1
    Names
    potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
    potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1
    potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019313.2 → NP_062186.1  small conductance calcium-activated potassium channel protein 1

      See identical proteins and their annotated locations for NP_062186.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/Swiss-Prot
      P70606
      UniProtKB/TrEMBL
      A0A8I6A039
      Related
      ENSRNOP00000042517.5, ENSRNOT00000044291.5
      Conserved Domains (3) summary
      smart01053
      Location:380 → 458
      CaMBD; Calmodulin binding domain
      pfam03530
      Location:92 → 199
      SK_channel; Calcium-activated SK potassium channel
      pfam07885
      Location:287 → 366
      Ion_trans_2; Ion channel

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      18608782..18632571
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063275667.1 → XP_063131737.1  small conductance calcium-activated potassium channel protein 1 isoform X2

      Related
      ENSRNOP00000108501.1, ENSRNOT00000142781.1

    2. XM_063275660.1 → XP_063131730.1  small conductance calcium-activated potassium channel protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8L2QL77

    3. XM_039094789.2 → XP_038950717.1  small conductance calcium-activated potassium channel protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A039, A0A8L2QL77
      Conserved Domains (3) summary
      smart01053
      Location:380 → 455
      CaMBD; Calmodulin binding domain
      pfam03530
      Location:92 → 199
      SK_channel; Calcium-activated SK potassium channel
      pfam07885
      Location:287 → 366
      Ion_trans_2; Ion channel

    4. XM_063275659.1 → XP_063131729.1  small conductance calcium-activated potassium channel protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8L2QL77

    5. XM_063275663.1 → XP_063131733.1  small conductance calcium-activated potassium channel protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8L2QL77

    6. XM_063275661.1 → XP_063131731.1  small conductance calcium-activated potassium channel protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8L2QL77

    7. XM_063275662.1 → XP_063131732.1  small conductance calcium-activated potassium channel protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8L2QL77

    8. XM_063275665.1 → XP_063131735.1  small conductance calcium-activated potassium channel protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8L2QL77

    9. XM_063275664.1 → XP_063131734.1  small conductance calcium-activated potassium channel protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8L2QL77

    10. XM_063275666.1 → XP_063131736.1  small conductance calcium-activated potassium channel protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8L2QL77
      Related
      ENSRNOP00000073862.3, ENSRNOT00000080467.3

    11. XM_063275658.1 → XP_063131728.1  small conductance calcium-activated potassium channel protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8L2QL77

    RNA

    1. XR_010058310.1 RNA Sequence

    2. XR_005494664.2 RNA Sequence

    3. XR_005494662.2 RNA Sequence

    4. XR_010058309.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P70606.2 GenPept UniProtKB/Swiss-Prot:P70606

    Gene LinkOut

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