Slc1a1 solute carrier family 1 member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc1a1provided by RGD
Official Full Name: solute carrier family 1 member 1provided by RGD
Primary source: RGD:3696
See related: EnsemblRapid:ENSRNOG00000014816 AllianceGenome:RGD:3696
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Eaac1; Eaat3; REAAC1
Summary: Enables amino acid transmembrane transporter activity; glutamate binding activity; and identical protein binding activity. Involved in L-glutamate transmembrane transport. Located in several cellular components, including dendrite; perikaryon; and perisynaptic space. Human ortholog(s) of this gene implicated in dicarboxylic aminoaciduria and schizophrenia 18. Orthologous to human SLC1A1 (solute carrier family 1 member 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 585.4), Brain (RPKM 203.0) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 1q52

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (235963455..236043572)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (226549932..226631925)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (246955017..247035159)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pre-Steady-State Kinetics and Reverse Transport in Rat Glutamate Transporter EAAC1 with an Immobilized Transport Domain.
Title: Pre-Steady-State Kinetics and Reverse Transport in Rat Glutamate Transporter EAAC1 with an Immobilized Transport Domain.
NCX1 and EAAC1 transporters are involved in the protective action of glutamate in an in vitro Alzheimer's disease-like model.
Title: NCX1 and EAAC1 transporters are involved in the protective action of glutamate in an in vitro Alzheimer's disease-like model.
miR-101b targets the neuronal glutamate transporter SLC1A1. Both mRNA and protein levels of SLC1A1 were found to be upregulated in the prefrontal cortex of rats genetically predisposed to develop major depressive disorder.
Title: MicroRNA 101b Is Downregulated in the Prefrontal Cortex of a Genetic Model of Depression and Targets the Glutamate Transporter SLC1A1 (EAAT3) in Vitro.
Numb is a pivotal adaptor protein that mediates the subcellular localization of EAAT3 through binding the YxNxxF (where x stands for any amino acid) motif.
Title: Numb directs the subcellular localization of EAAT3 through binding the YxNxxF motif.
Exercise-Mediated Increase in Nigral EAAC1 in aging rats.
Title: Exercise-Mediated Increase in Nigral Tyrosine Hydroxylase Is Accompanied by Increased Nigral GFR-α1 and EAAC1 Expression in Aging Rats.
results suggest that the down-regulation of morphine-dependent EAAT3 expression in primary hippocampal cultures may be mediated by micro opioid receptor and delta opioid receptor and that kappa opioid receptor may not contribute significantly to this effect
Title: Chronic exposure to morphine decreases the expression of EAAT3 via opioid receptors in hippocampal neurons.
Chronic postnatal stress led to decreased Eaat3 expression in hippocampus and frontal cortex.
Title: Chronic postnatal stress induces voluntary alcohol intake and modifies glutamate transporters in adolescent rats.
data indicate that NRG1 induced the up-regulation of EAAC1 in primary cortical neurons with an increase in glutamate uptake
Title: Neuregulin 1 Controls Glutamate Uptake by Up-regulating Excitatory Amino Acid Carrier 1 (EAAC1).
changes of phosphorylated GluR1 subunit of AMPAR protein level in the hippocampus and frontal cortex, as well as markedly decreased EAAT2 mRNA expression in the hippocampus, striatum and frontal cortex and EAAT3 mRNA expression in the hippocampus
Title: Involvement of pGluR1, EAAT2 and EAAT3 in offspring depression induced by prenatal stress.
Nicotine decreases EAAT3 activity, and this inhibition seems to be dependent on PKC and PI3K.
Title: Nicotine decreases the activity of glutamate transporter type 3.

Submit: New GeneRIF Correction See all GeneRIFs (56)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BF399845 (e-PCR)
- UniSTS:247817

RH130525 (e-PCR)
- UniSTS:213809

BE120573 (e-PCR)
- UniSTS:247358

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables D-aspartate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-amino acid transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables L-aspartate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-glutamate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-glutamate transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables L-glutamate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables acidic amino acid transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables chloride transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables chloride transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables cysteine transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables cysteine transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables glutamate binding	IDA Inferred from Direct Assay more info	PubMed
enables glutamate:sodium symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutamate:sodium symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables glutamate:sodium symporter activity	ISO Inferred from Sequence Orthology more info
enables high-affinity L-glutamate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables high-affinity L-glutamate transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monoatomic anion channel activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables symporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in D-aspartate import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in D-aspartate transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled dopamine receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in L-aspartate import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in L-aspartate import across plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in L-aspartate transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in L-glutamate import	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within L-glutamate import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in L-glutamate import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in L-glutamate import across plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in L-glutamate transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-glutamate transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in L-glutamate transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within L-glutamate transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in L-glutamate transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in activation of protein kinase B activity	ISO Inferred from Sequence Orthology more info
involved_in adult behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within behavioral fear response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within blood vessel morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in brain development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to ammonium ion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to bisphenol A	ISO Inferred from Sequence Orthology more info
involved_in cellular response to cocaine	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to mercury ion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to organic cyclic compound	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in chloride transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in chloride transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in conditioned place preference	ISO Inferred from Sequence Orthology more info
involved_in cysteine transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in cysteine transport	ISO Inferred from Sequence Orthology more info
involved_in cysteine transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in cytokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in dopamine metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of protein localization	ISO Inferred from Sequence Orthology more info
involved_in gene expression	ISO Inferred from Sequence Orthology more info
involved_in glutamate receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in glutathione biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glutathione metabolic process	ISO Inferred from Sequence Orthology more info
involved_in glutathione metabolic process	ISO Inferred from Sequence Orthology more info
involved_in grooming behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart contraction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intracellular glutamate homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intracellular zinc ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intracellular zinc ion homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within learning or memory	ISO Inferred from Sequence Orthology more info
involved_in locomotory behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within long-term synaptic potentiation	ISO Inferred from Sequence Orthology more info
involved_in long-term synaptic potentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within maintenance of blood-brain barrier	ISO Inferred from Sequence Orthology more info
involved_in memory	ISO Inferred from Sequence Orthology more info
involved_in motor behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within motor neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in neurogenesis	ISO Inferred from Sequence Orthology more info
involved_in neuron apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neurotransmitter receptor transport to plasma membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of heart rate	ISO Inferred from Sequence Orthology more info
involved_in postsynaptic modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in regulation of heart rate	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of protein targeting to membrane	ISO Inferred from Sequence Orthology more info
involved_in response to amphetamine	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to anesthetic	ISO Inferred from Sequence Orthology more info
involved_in response to anesthetic	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to axon injury	ISO Inferred from Sequence Orthology more info
involved_in response to axon injury	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to decreased oxygen levels	ISO Inferred from Sequence Orthology more info
involved_in response to decreased oxygen levels	ISO Inferred from Sequence Orthology more info
involved_in response to morphine	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
involved_in retina development in camera-type eye	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within retina layer formation	ISO Inferred from Sequence Orthology more info
involved_in retina layer formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within righting reflex	ISO Inferred from Sequence Orthology more info
involved_in superoxide metabolic process	ISO Inferred from Sequence Orthology more info
involved_in synapse organization	ISO Inferred from Sequence Orthology more info
involved_in zinc ion transmembrane transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Schaffer collateral - CA1 synapse	ISO Inferred from Sequence Orthology more info
located_in apical dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in asymmetric synapse	IDA Inferred from Direct Assay more info	PubMed
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axon terminus	IDA Inferred from Direct Assay more info	PubMed
located_in cell periphery	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
is_active_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
is_active_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendritic shaft	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
located_in distal dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in early endosome membrane	IEA Inferred from Electronic Annotation more info
located_in early endosome membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in glial cell projection	IDA Inferred from Direct Assay more info	PubMed
located_in late endosome membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in neuron projection	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed
located_in perisynaptic space	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in presynapse	IDA Inferred from Direct Assay more info	PubMed
located_in proximal dendrite	IDA Inferred from Direct Assay more info	PubMed
is_active_in recycling endosome	ISO Inferred from Sequence Orthology more info
located_in recycling endosome membrane	IEA Inferred from Electronic Annotation more info
located_in recycling endosome membrane	ISO Inferred from Sequence Orthology more info
located_in synapse	IEA Inferred from Electronic Annotation more info
is_active_in synapse	ISO Inferred from Sequence Orthology more info
located_in synaptic cleft	IDA Inferred from Direct Assay more info	PubMed
located_in vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: excitatory amino acid transporter 3

Names: Solute carrier family 1 A1 (brain glutamate transporter); excitatory amino-acid carrier 1; sodium-dependent glutamate/aspartate transporter 3; solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.