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    FLYWCH2 FLYWCH family member 2 [ Homo sapiens (human) ]

    Gene ID: 114984, updated on 10-Dec-2024

    Summary

    Official Symbol
    FLYWCH2provided by HGNC
    Official Full Name
    FLYWCH family member 2provided by HGNC
    Primary source
    HGNC:HGNC:25178
    See related
    Ensembl:ENSG00000162076 AllianceGenome:HGNC:25178
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Enables RNA binding activity. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in spleen (RPKM 10.8), prostate (RPKM 8.6) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See FLYWCH2 in Genome Data Viewer
    Location:
    16p13.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (2883195..2899382)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (2909827..2926022)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (2933196..2949383)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:2907556-2908156 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:2908157-2908757 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:2908758-2909357 Neighboring gene serine protease 22 Neighboring gene uncharacterized LOC101929566 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10284 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10285 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10286 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:2932133-2932633 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7077 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7078 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7079 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:2955125-2955625 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7081 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7082 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7083 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7084 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:2962376-2962565 Neighboring gene FLYWCH-type zinc finger 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:2974631-2975496 Neighboring gene ribosomal protein L23a pseudogene 86 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr16:2978151-2978660 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:2988192-2988805 Neighboring gene uncharacterized LOC105371055 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3005307-3006228

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001142499.1NP_001135971.1  FLYWCH family member 2

      See identical proteins and their annotated locations for NP_001135971.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      AL542248, BC014089, BG120460, CA413438, DB455461
      Consensus CDS
      CCDS10482.1
      UniProtKB/Swiss-Prot
      Q96CP2
      Related
      ENSP00000293981.6, ENST00000293981.10
      Conserved Domains (1) summary
      pfam15423
      Location:1106
      FLYWCH_N; FLYWCH-type zinc finger-containing protein
    2. NM_001142500.1NP_001135972.1  FLYWCH family member 2

      See identical proteins and their annotated locations for NP_001135972.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      BC014089, BG120460, BI825861, CA413438, DB455461
      Consensus CDS
      CCDS10482.1
      UniProtKB/Swiss-Prot
      Q96CP2
      Conserved Domains (1) summary
      pfam15423
      Location:1106
      FLYWCH_N; FLYWCH-type zinc finger-containing protein
    3. NM_138439.3NP_612448.1  FLYWCH family member 2

      See identical proteins and their annotated locations for NP_612448.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.
      Source sequence(s)
      BC014089, BG120460, CA413438, DB455461
      Consensus CDS
      CCDS10482.1
      UniProtKB/Swiss-Prot
      Q96CP2
      Related
      ENSP00000380159.3, ENST00000396958.8
      Conserved Domains (1) summary
      pfam15423
      Location:1106
      FLYWCH_N; FLYWCH-type zinc finger-containing protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      2883195..2899382
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005255078.6XP_005255135.1  FLYWCH family member 2 isoform X1

      See identical proteins and their annotated locations for XP_005255135.1

      UniProtKB/Swiss-Prot
      Q96CP2
      Conserved Domains (1) summary
      pfam15423
      Location:1106
      FLYWCH_N; FLYWCH-type zinc finger-containing protein
    2. XM_047433572.1XP_047289528.1  FLYWCH family member 2 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      2909827..2926022
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054379508.1XP_054235483.1  FLYWCH family member 2 isoform X1

      UniProtKB/Swiss-Prot
      Q96CP2