Myh3 myosin heavy chain 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Myh3provided by RGD
Official Full Name: myosin heavy chain 3provided by RGD
Primary source: RGD:3138
See related: EnsemblRapid:ENSRNOG00000046276 AllianceGenome:RGD:3138
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Myhse; RNMHCG
Summary: Predicted to enable ATP hydrolysis activity; actin filament binding activity; and microfilament motor activity. Predicted to be involved in ATP metabolic process and skeletal muscle contraction. Predicted to be located in contractile muscle fiber. Predicted to be part of myosin II complex. Predicted to be active in cytoplasm and myosin filament. Human ortholog(s) of this gene implicated in contractures, pterygia, and spondylocarpotarsal fusion syndrome 1A; contractures, pterygia, and spondylocarpotarsal fusion syndrome 1B; distal arthrogryposis type 2A; distal arthrogryposis type 2B; and distal arthrogryposis type 2B3. Orthologous to human MYH3 (myosin heavy chain 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward (RPKM 3605.2) See more
Orthologs: human mouse all
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Genomic context

Location:: 10q24

Exon count:: 41

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (52269185..52293000)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (51770177..51793994)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (53621375..53645194)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

METTL3 achieves lipopolysaccharide-induced myocardial injury via m[6]A-dependent stabilization of Myh3 mRNA.
Title: METTL3 achieves lipopolysaccharide-induced myocardial injury via m(6)A-dependent stabilization of Myh3 mRNA.
IGF1 downregulates embryonic myosin heavy chain in myoblast nuclei [embryonic myosin heavy chain (eMyHC)]
Title: Insulin-like growth factor-I downregulates embryonic myosin heavy chain (eMyHC) in myoblast nuclei.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D10Wox11 (e-PCR)
- UniSTS:118028

D10Mgh20 (e-PCR)
- UniSTS:120126

PMC133998P1 (e-PCR)
- UniSTS:270706

RH134730 (e-PCR)
- UniSTS:218008

D10Rat32 (e-PCR)
- UniSTS:118173

D10Arb5 (e-PCR), detects polymorphism
- UniSTS:226261

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	ISO Inferred from Sequence Orthology more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables cytoskeletal motor activity	IEA Inferred from Electronic Annotation more info
enables microfilament motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables microfilament motor activity	IEA Inferred from Electronic Annotation more info
enables microfilament motor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in ATP metabolic process	IEA Inferred from Electronic Annotation more info
involved_in ATP metabolic process	ISO Inferred from Sequence Orthology more info
involved_in muscle contraction	IBA Inferred from Biological aspect of Ancestor more info
involved_in skeletal muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in skeletal muscle contraction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in contractile muscle fiber	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in myofibril	IEA Inferred from Electronic Annotation more info
part_of myosin II complex	IBA Inferred from Biological aspect of Ancestor more info
part_of myosin complex	IEA Inferred from Electronic Annotation more info
part_of myosin complex	ISO Inferred from Sequence Orthology more info
is_active_in myosin filament	IBA Inferred from Biological aspect of Ancestor more info
located_in myosin filament	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: myosin-3

Names: myosin heavy chain, fast skeletal muscle, embryonic; myosin heavy polypeptide 3; myosin, heavy chain 3, skeletal muscle, embryonic; myosin, heavy polypeptide 3, skeletal muscle, embryonic

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012604.1 → NP_036736.1 myosin-3

See identical proteins and their annotated locations for NP_036736.1

Status: PROVISIONAL

Source sequence(s)

X04267

UniProtKB/Swiss-Prot

P12847

UniProtKB/TrEMBL

A6HFH7, G3V6D8

Related

ENSRNOP00000004147.3, ENSRNOT00000004147.7

Conserved Domains (9) summary

cd14913
Location:100 → 767

MYSc_Myh3; class II myosin heavy chain 3, motor domain

pfam00063
Location:88 → 767

Myosin_head; Myosin head (motor domain)

pfam01576
Location:847 → 1924

Myosin_tail_1; Myosin tail

pfam02736
Location:36 → 73

Myosin_N; Myosin N-terminal SH3-like domain

pfam07851
Location:1739 → 1828

TMPIT; TMPIT-like protein

cl00459
Location:1296 → 1408

MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily

cl03075
Location:843 → 962

GrpE; nucleotide exchange factor GrpE

cl19764
Location:1373 → 1506

COG6; Conserved oligomeric complex COG6

cl23720
Location:962 → 1095

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)